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- Mifepristone abstract "Mifepristone (or RU-486) is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. The compound is a 19-nor steroid with substitutions at positions C11 and C17 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl] 17 alpha-[1-propynyl]estra-4,9-dien-3-one), which antagonizes cortisol action competitively at the receptor level.Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. Mifepristone is also a powerful glucocorticoid receptor antagonist, and has occasionally been used in refractory Cushing's Syndrome (due to ectopic/neoplastic ACTH/Cortisol secretion). During early trials, it was known as RU-38486 or simply RU-486, its designation at the Roussel Uclaf company, which designed the drug. The drug was initially made available in France, and other countries then followed—often amid controversy. It is marketed under tradenames Korlym and Mifeprex, according to FDA Orange Book.Mifepristone was the first antiprogestin to be developed and it has been evaluated extensively for its use as an abortifacient. The original target for the research group, however, was the discovery and development of compounds with antiglucocorticoid properties. It is these antiglucocorticoid properties that are of great interest in the treatment of severe mood disorders and psychosis. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.".
- Mifepristone atcPrefix "G03".
- Mifepristone atcSuffix "XB01".
- Mifepristone bioavailability "69.0".
- Mifepristone casNumber "84371-65-3".
- Mifepristone chEBI "50692".
- Mifepristone drugbank "DB00834".
- Mifepristone fdaUniiCode "320T6RNW1F".
- Mifepristone iupacName "11β-[p-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one".
- Mifepristone pubchem "55245".
- Mifepristone thumbnail Mifepristone.svg?width=300.
- Mifepristone wikiPageExternalLink www.earlyoptionpill.com.
- Mifepristone wikiPageExternalLink prescribing071905.pdf.
- Mifepristone wikiPageExternalLink mifepristone.
- Mifepristone wikiPageExternalLink article_73.asp.
- Mifepristone wikiPageExternalLink www.ru486.org.au.
- Mifepristone wikiPageID "181415".
- Mifepristone wikiPageRevisionID "606809067".
- Mifepristone atcPrefix "G03".
- Mifepristone atcSuffix "XB01".
- Mifepristone bioavailability "69.0".
- Mifepristone boilingPoint "629".
- Mifepristone c "29".
- Mifepristone casNumber "84371".
- Mifepristone chebi "50692".
- Mifepristone chembl "157".
- Mifepristone chemspiderid "49889".
- Mifepristone date "November 2013".
- Mifepristone density "1.189".
- Mifepristone drugbank "DB00834".
- Mifepristone eliminationHalfLife "64800.0".
- Mifepristone excretion "Fecal: 83%; Renal: 9%".
- Mifepristone h "35".
- Mifepristone hasPhotoCollection Mifepristone.
- Mifepristone image "Mifepristona3D.png".
- Mifepristone inchi "1".
- Mifepristone iupacName "11".
- Mifepristone iupharLigand "2805".
- Mifepristone kegg "D00585".
- Mifepristone legalUs "Rx-only".
- Mifepristone medlineplus "a600042".
- Mifepristone meltingPoint "194".
- Mifepristone metabolism Liver.
- Mifepristone molecularWeight "429.6".
- Mifepristone n "1".
- Mifepristone o "2".
- Mifepristone pregnancyCategory "Used for terminating pregnancy".
- Mifepristone pregnancyUs "X".
- Mifepristone proteinBound "98.0".
- Mifepristone pubchem "55245".
- Mifepristone routesOfAdministration Oral_administration.
- Mifepristone smiles "O=C5\C=C4/CCC5".
- Mifepristone stdinchi "1".
- Mifepristone stdinchikey "VKHAHZOOUSRJNA-GCNJZUOMSA-N".
- Mifepristone sure "y".
- Mifepristone unii "320".
- Mifepristone verifiedrevid "443306800".
- Mifepristone watchedfields "changed".
- Mifepristone width "200".
- Mifepristone subject Category:Abortifacients.
- Mifepristone subject Category:Abortion.
- Mifepristone subject Category:Alkynes.
- Mifepristone subject Category:Anilines.
- Mifepristone subject Category:Antiandrogens.
- Mifepristone subject Category:Antiglucocorticoids.
- Mifepristone subject Category:Antiprogestogens.
- Mifepristone subject Category:Methods_of_abortion.
- Mifepristone type Drug.
- Mifepristone type DrugProduct.
- Mifepristone type FunctionalSubstance.
- Mifepristone comment "Mifepristone (or RU-486) is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties.".
- Mifepristone label "Mifepriston".
- Mifepristone label "Mifepriston".
- Mifepristone label "Mifepriston".
- Mifepristone label "Mifepristona".
- Mifepristone label "Mifepristona".
- Mifepristone label "Mifepristone".
- Mifepristone label "Mifepristone".
- Mifepristone label "Mifépristone".
- Mifepristone label "Мифепристон".
- Mifepristone label "ミフェプリストン".
- Mifepristone label "美服培酮".
- Mifepristone sameAs Mifepriston.
- Mifepristone sameAs Mifepriston.
- Mifepristone sameAs Mifepristona.
- Mifepristone sameAs Mifépristone.
- Mifepristone sameAs Mifepristone.
- Mifepristone sameAs ミフェプリストン.
- Mifepristone sameAs Mifepriston.
- Mifepristone sameAs Mifepriston.
- Mifepristone sameAs Mifepristona.
- Mifepristone sameAs m.018svj.
- Mifepristone sameAs Q411240.
- Mifepristone sameAs Q411240.
- Mifepristone sameAs DB00834.
- Mifepristone sameAs 4196.
- Mifepristone wasDerivedFrom Mifepristone?oldid=606809067.
- Mifepristone depiction Mifepristone.svg.
- Mifepristone isPrimaryTopicOf Mifepristone.