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- Mildronate abstract "Mildronate (also known as THP, MET-88, Meldonium, Mildronāts or Quaterine) is a clinically used anti-ischemic & nootropic drug that is currently manufactured and marketed by Grindeks, a pharmaceutical company based in Latvia.Mildronate is clinically used to treat angina and myocardial infarction. The first clinical trial testing the efficacy of using a combination of mildronate and lisinopril, an angiotensin-converting enzyme inhibitor, to treat chronic heart failure was reported in 2005. The report demonstrated that the combined treatment of mildronate and lisinopril may improve the quality of life, exercise capacity and mechanisms of peripheral circulation of patients with chronic heart failure. A later report in 2008 further demonstrated the efficacy of combined mildronate-lisinopril treatment by showing improved carotid baroreceptor reflex in patients with chronic heart failure. In February 2010, the clinical trial testing the efficacy and safety of mildronate treatment in combination with standard exercise tolerance therapy on angina patients was successfully completed. The studies revealed that mildronate treatment significantly improves the exercise tolerance of stable angina patients. A phase II clinical trial on the efficacy and safety of mildronate for acute ischemic stroke was completed in August 2013 and the studies showed that mildronate is as effective and safe as cinepazide injection.Besides clinical trials, a number of scientific research projects have also been conducted to improve the efficacy of mildronate and its applicability to other diseases. For example, a report published by Vilskersts et al. suggested that the effect of mildronate treatment may be enhanced with co-treatment of other compounds such as orotic acid.Using animal models, the applications of mildronate, sometimes in tandem with other drugs such as metformin, have shown beneficial effects on neurological disorder and diabetes.Mildronate may also be beneficial for the treatment of seizures and alcohol intoxication.Recent reports also suggest that mildronate may improve the ability of learning and memory, as the drug changes the expression of hippocampal proteins related to synaptic plasticity using rat model.Mildronate was reported to elevate the concentrations of γ-butyrobetaine hydroxylase in testes tissues; in addition, long term (90 days) administration of mildronate was reported to improve sexual performance, sperm motility and concentration of testosterone in boars, although further studies are needed to confirm the potential of using mildronate as a sperm motility and sperm quality-enhancing agent.To date, mildronate is one of Latvia's most exported products, and can be readily obtained in countries including Russia, Ukraine, Moldova, Belarus, Azerbaijan and Armenia.".
- Mildronate iupacName "2-(2-carboxyethyl)-1,1,1-trimethylhydrazinium".
- Mildronate thumbnail Mildronate.png?width=300.
- Mildronate wikiPageExternalLink m5199.
- Mildronate wikiPageID "32592400".
- Mildronate wikiPageRevisionID "602111142".
- Mildronate hasPhotoCollection Mildronate.
- Mildronate imagefile "Mildronate.png".
- Mildronate iupacname "2".
- Mildronate subject Category:Antianginals.
- Mildronate subject Category:Drugs_acting_on_the_cardiovascular_system.
- Mildronate subject Category:Ischemic_heart_diseases.
- Mildronate subject Category:Latvian_inventions.
- Mildronate type Agent114778436.
- Mildronate type CausalAgent100007347.
- Mildronate type Drug103247620.
- Mildronate type DrugsActingOnTheCardiovascularSystem.
- Mildronate type Matter100020827.
- Mildronate type PhysicalEntity100001930.
- Mildronate type Substance100020090.
- Mildronate type ChemicalCompound.
- Mildronate type ChemicalSubstance.
- Mildronate type ChemicalObject.
- Mildronate type Thing.
- Mildronate comment "Mildronate (also known as THP, MET-88, Meldonium, Mildronāts or Quaterine) is a clinically used anti-ischemic & nootropic drug that is currently manufactured and marketed by Grindeks, a pharmaceutical company based in Latvia.Mildronate is clinically used to treat angina and myocardial infarction. The first clinical trial testing the efficacy of using a combination of mildronate and lisinopril, an angiotensin-converting enzyme inhibitor, to treat chronic heart failure was reported in 2005.".
- Mildronate label "Mildronate".
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- Mildronate sameAs Mildronate.
- Mildronate wasDerivedFrom Mildronate?oldid=602111142.
- Mildronate depiction Mildronate.png.
- Mildronate isPrimaryTopicOf Mildronate.