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- Morpholino abstract "Morpholino, in molecular biology, describes a molecule in a particular structural family that is used to modify gene expression. Morpholino oligomers (oligos) are a class of antisense, a technology used to block access of other molecules to specific sequences within nucleic acids. Morpholinos block small (~25 base) regions of the base-pairing surfaces of ribonucleic acid (RNA). Most Morpholinos are used as research tools for reverse genetics by knocking down gene function. This article discusses only the Morpholino antisense oligos, which are nucleic acid analogs. The word "morpholino" can occur in other chemical names, referring to chemicals containing a six-membered morpholine ring. To help avoid confusion with other morpholine-containing molecules, when describing oligos "Morpholino" is often capitalized as a trade name, though this usage is not consistent throughout the scientific literature. Morpholinos are sometimes referred to as "PMO" (phosphorodiamidate morpholino oligo).Gene knockdown is achieved by preventing cells from making a targeted protein. Morpholinos can also modify the splicing of pre-mRNA. Knocking down gene expression is a powerful method for learning about the function of a particular protein; in similar manner, causing a specific exon to be spliced out of a protein can help to determine the function of the protein moiety encoded by that exon or can sometimes knock down the protein activity altogether. These molecules have been applied to studies in several model organisms, including mice, zebrafish, frogs, and sea urchins.Morpholinos are also in development as pharmaceutical therapeutics targeted against pathogenic organisms such as bacteria or viruses and for amelioration of genetic diseases. These synthetic oligos were conceived by James E. Summerton (Gene Tools, LLC) and developed in collaboration with Dwight D. Weller (formerly Antivirals Inc, renamed AVI BioPharma Inc., renamed Sarepta_Therapeutics Inc.).".
- Morpholino thumbnail MorpholinoHeteroduplex.png?width=300.
- Morpholino wikiPageExternalLink issuetoc?ID=85006212.
- Morpholino wikiPageID "1078762".
- Morpholino wikiPageRevisionID "595462663".
- Morpholino hasPhotoCollection Morpholino.
- Morpholino subject Category:Molecular_genetics.
- Morpholino subject Category:Morpholines.
- Morpholino subject Category:Nucleic_acids.
- Morpholino subject Category:Phosphoramidates.
- Morpholino type Abstraction100002137.
- Morpholino type Chemical114806838.
- Morpholino type Compound114818238.
- Morpholino type Macromolecule114944888.
- Morpholino type Material114580897.
- Morpholino type Matter100020827.
- Morpholino type Molecule114682133.
- Morpholino type NucleicAcid114964129.
- Morpholino type NucleicAcids.
- Morpholino type OrganicCompound114727670.
- Morpholino type Part113809207.
- Morpholino type PhysicalEntity100001930.
- Morpholino type Relation100031921.
- Morpholino type Substance100019613.
- Morpholino type Thing100002452.
- Morpholino type Unit109465459.
- Morpholino comment "Morpholino, in molecular biology, describes a molecule in a particular structural family that is used to modify gene expression. Morpholino oligomers (oligos) are a class of antisense, a technology used to block access of other molecules to specific sequences within nucleic acids. Morpholinos block small (~25 base) regions of the base-pairing surfaces of ribonucleic acid (RNA). Most Morpholinos are used as research tools for reverse genetics by knocking down gene function.".
- Morpholino label "Morfolino".
- Morpholino label "Morpholino".
- Morpholino label "Morpholino".
- Morpholino label "Morpholino".
- Morpholino label "Морфолино".
- Morpholino label "嗎啉基".
- Morpholino sameAs Morpholino.
- Morpholino sameAs Morpholino.
- Morpholino sameAs Morfolino.
- Morpholino sameAs Morfolino.
- Morpholino sameAs m.0443j2.
- Morpholino sameAs Q424607.
- Morpholino sameAs Q424607.
- Morpholino sameAs Morpholino.
- Morpholino wasDerivedFrom Morpholino?oldid=595462663.
- Morpholino depiction MorpholinoHeteroduplex.png.
- Morpholino isPrimaryTopicOf Morpholino.