Matches in DBpedia 2014 for { <http://dbpedia.org/resource/N-Acetylserotonin> ?p ?o. }
Showing items 1 to 72 of
72
with 100 items per page.
- N-Acetylserotonin abstract "N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase (AANAT) and is converted to melatonin by acetylserotonin O-methyltransferase (ASMT). Like melatonin, NAS is an agonist at the melatonin receptors MT1, MT2, and MT3, and may be considered to be a neurotransmitter. In addition, NAS is distributed in some areas of the brain where serotonin and melatonin are not, suggesting that it may have unique central duties of its own instead of merely functioning as a precursor in the synthesis of melatonin.Recently, NAS has been shown to act as a potent TrkB receptor agonist, while serotonin and melatonin are not. It produces robust antidepressant, neuroprotective, and neurotrophic effects that are TrkB-mediated. In addition, AANAT knockout mice which lack NAS display significantly greater immobility times versus control mice in assays of depression like the forced swim test.NAS may also play a major role in the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs). The SSRI fluoxetine and the MAO-A inhibitor clorgyline upregulate AANAT indirectly through serotonergic mechanisms and thereby increase NAS levels after chronic administration, and this correlates with the onset of their antidepressant effects. Furthermore, light exposure inhibits the synthesis of NAS and reduces the antidepressant effects of MAOIs. These data strongly support a role for NAS in mood regulation and in antidepressant-induced therapeutic benefits.Through a currently unidentified mechanism, NAS may be the cause of the orthostatic hypotension seen with clinical treatment of MAOIs. It reduces blood pressure in rodents, and pinealectomy (the pineal gland being a major site of NAS and melatonin synthesis) abolishes the hypotensive effects of clorgyline. Why orthostatic hypotension is commonly seen with MAOIs but not SSRIs (both of which increase NAS levels) however, is unknown.".
- N-Acetylserotonin iupacName "N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide".
- N-Acetylserotonin thumbnail N-Acetylserotonin.png?width=300.
- N-Acetylserotonin wikiPageID "11395125".
- N-Acetylserotonin wikiPageRevisionID "592608832".
- N-Acetylserotonin hasPhotoCollection N-Acetylserotonin.
- N-Acetylserotonin imagefile "N-Acetylserotonin-3D-sticks.png".
- N-Acetylserotonin imagefile "N-Acetylserotonin.png".
- N-Acetylserotonin iupacname "N-[2-ethyl]acetamide".
- N-Acetylserotonin name "N-Acetylserotonin".
- N-Acetylserotonin othernames "N-acetyl-5-hydroxytryptamine, N-acetyl-5-HT".
- N-Acetylserotonin verifiedfields "changed".
- N-Acetylserotonin verifiedrevid "462257090".
- N-Acetylserotonin watchedfields "changed".
- N-Acetylserotonin subject Category:Acetamides.
- N-Acetylserotonin subject Category:Antioxidants.
- N-Acetylserotonin subject Category:Biogenic_amines.
- N-Acetylserotonin subject Category:Circadian_rhythm.
- N-Acetylserotonin subject Category:Hormones_of_the_pineal_gland.
- N-Acetylserotonin subject Category:Phenols.
- N-Acetylserotonin subject Category:Tryptamine_alkaloids.
- N-Acetylserotonin type Abstraction100002137.
- N-Acetylserotonin type Acetamide114711197.
- N-Acetylserotonin type Acetamides.
- N-Acetylserotonin type AliphaticCompound114601294.
- N-Acetylserotonin type Alkaloid114712692.
- N-Acetylserotonin type Amide114724264.
- N-Acetylserotonin type Amine114739004.
- N-Acetylserotonin type Attribute100024264.
- N-Acetylserotonin type BiogenicAmines.
- N-Acetylserotonin type BiologicalTime115116532.
- N-Acetylserotonin type BodySubstance105263850.
- N-Acetylserotonin type Chemical114806838.
- N-Acetylserotonin type CircadianRhythm115135700.
- N-Acetylserotonin type CircadianRhythms.
- N-Acetylserotonin type Compound114818238.
- N-Acetylserotonin type Hormone105407119.
- N-Acetylserotonin type HormonesOfThePinealGland.
- N-Acetylserotonin type LiquidBodySubstance105397468.
- N-Acetylserotonin type Material114580897.
- N-Acetylserotonin type Matter100020827.
- N-Acetylserotonin type MethaneSeries114951377.
- N-Acetylserotonin type NaturalTryptamineAlkaloids.
- N-Acetylserotonin type OrganicCompound114727670.
- N-Acetylserotonin type Part113809207.
- N-Acetylserotonin type Phenol114989545.
- N-Acetylserotonin type Phenols.
- N-Acetylserotonin type PhysicalEntity100001930.
- N-Acetylserotonin type Relation100031921.
- N-Acetylserotonin type Secretion105404728.
- N-Acetylserotonin type Substance100019613.
- N-Acetylserotonin type Time100028270.
- N-Acetylserotonin type ChemicalCompound.
- N-Acetylserotonin type ChemicalSubstance.
- N-Acetylserotonin type ChemicalSubstanceType.
- N-Acetylserotonin type ChemicalObject.
- N-Acetylserotonin type Thing.
- N-Acetylserotonin comment "N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase (AANAT) and is converted to melatonin by acetylserotonin O-methyltransferase (ASMT). Like melatonin, NAS is an agonist at the melatonin receptors MT1, MT2, and MT3, and may be considered to be a neurotransmitter.".
- N-Acetylserotonin label "N-Acetylserotonin".
- N-Acetylserotonin label "N-acetilserotonina".
- N-Acetylserotonin label "N-乙酰血清素".
- N-Acetylserotonin sameAs N-acetilserotonina.
- N-Acetylserotonin sameAs ノルメラトニン.
- N-Acetylserotonin sameAs m.02rb1q0.
- N-Acetylserotonin sameAs Q4847704.
- N-Acetylserotonin sameAs Q4847704.
- N-Acetylserotonin sameAs DB04275.
- N-Acetylserotonin sameAs N-Acetylserotonin.
- N-Acetylserotonin wasDerivedFrom N-Acetylserotonin?oldid=592608832.
- N-Acetylserotonin depiction N-Acetylserotonin.png.
- N-Acetylserotonin isPrimaryTopicOf N-Acetylserotonin.
- N-Acetylserotonin name "N-Acetylserotonin".