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- NGD-4715 abstract "NGD-4715 is a drug developed by Neurogen, which acts as a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has anxiolytic, antidepressant and anorectic effects, and it has successfully passed Phase I clinical trials in humans.Neurogen was acquired by Ligand Pharmaceuticals in August, 2009, and NGD-4715 was not listed among the key assets in the Business Wire article. All four laboratories were closed and sold, and no employees were retained. Neurogen's domain name is delisted. No reference to NGD-4715, nor MCH Antagonists exists on ligand.com as of 2011-09-04. Internet searches as of 2011-09-04 for Phase-II come up negative.An email to Ligand Investor Relation received this response on 2011-09-07:"NGD-4715, a MCH-1 antagonist, was under development at Neurogen for obesity. Neurogen terminated the program prior to Ligand’s acquisition. Ligand owns the wrights and currently has no plans for further development on the compound."".
- NGD-4715 casNumber "476322-70-0".
- NGD-4715 iupacName "1-(3,4-dimethoxybenzyl)-4-(5-bromo-6-methoxypyridin-2-yl)piperazine".
- NGD-4715 thumbnail NGD-4715_structure.png?width=300.
- NGD-4715 wikiPageExternalLink ligand.com.
- NGD-4715 wikiPageExternalLink neurogen.com.
- NGD-4715 wikiPageID "23508254".
- NGD-4715 wikiPageRevisionID "545664721".
- NGD-4715 br "1".
- NGD-4715 c "19".
- NGD-4715 casNumber "476322".
- NGD-4715 h "24".
- NGD-4715 hasPhotoCollection NGD-4715.
- NGD-4715 iupacName "1".
- NGD-4715 molecularWeight "422.315".
- NGD-4715 n "3".
- NGD-4715 o "3".
- NGD-4715 smiles "Brc1cccN3CCNCcccc2OC".
- NGD-4715 verifiedrevid "448981664".
- NGD-4715 subject Category:Anorectics.
- NGD-4715 subject Category:Antidepressants.
- NGD-4715 subject Category:Anxiolytics.
- NGD-4715 subject Category:Organobromides.
- NGD-4715 subject Category:Phenol_ethers.
- NGD-4715 subject Category:Piperazines.
- NGD-4715 subject Category:Pyridines.
- NGD-4715 type Drug.
- NGD-4715 type DrugProduct.
- NGD-4715 type FunctionalSubstance.
- NGD-4715 comment "NGD-4715 is a drug developed by Neurogen, which acts as a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has anxiolytic, antidepressant and anorectic effects, and it has successfully passed Phase I clinical trials in humans.Neurogen was acquired by Ligand Pharmaceuticals in August, 2009, and NGD-4715 was not listed among the key assets in the Business Wire article.".
- NGD-4715 label "NGD-4715".
- NGD-4715 sameAs m.06w453x.
- NGD-4715 sameAs Q6953947.
- NGD-4715 sameAs Q6953947.
- NGD-4715 wasDerivedFrom NGD-4715?oldid=545664721.
- NGD-4715 depiction NGD-4715_structure.png.
- NGD-4715 isPrimaryTopicOf NGD-4715.