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- Naluzotan abstract "Naluzotan (INN, USAN; PRX-00023) is a serotonergic drug of the phenylpiperazine class that was under investigation by EPIX Pharmaceuticals Inc for the treatment of generalized anxiety disorder and major depressive disorder. It acts as a selective and potent 5-HT1A receptor partial agonist, readily stimulating prolactin responses, though it has also been found to bind to and activate the σ receptor. Naluzotan was well tolerated in clinical trials, with more patients in the control group dropping out due to adverse effects than in the active group in one study. The most frequently reported side effect was headache in 15% of patients (compared to 10% for placebo). In addition, naluzotan demonstrated significant antidepressant and anxiolytic effects as per the HAM-D and MADRS and the HAM-A, respectively, in some trials, but in others it did not. In the end it was not found to be significantly superior enough to placebo and development was stopped.".
- Naluzotan atcPrefix "None".
- Naluzotan casNumber "740873-06-7".
- Naluzotan fdaUniiCode "LQ54E5B4EW".
- Naluzotan iupacName "N-(3-{4-[4-(1-cyclohexylmethanesulfonamido)butyl]piperazin-1-yl}phenyl)acetamide".
- Naluzotan pubchem "11430856".
- Naluzotan thumbnail PRX-00023_structure.png?width=300.
- Naluzotan wikiPageID "22627114".
- Naluzotan wikiPageRevisionID "592611349".
- Naluzotan atcPrefix "None".
- Naluzotan c "23".
- Naluzotan casNumber "740873".
- Naluzotan chemspiderid "9605731".
- Naluzotan h "38".
- Naluzotan hasPhotoCollection Naluzotan.
- Naluzotan iupacName "N-acetamide".
- Naluzotan molecularWeight "450.638".
- Naluzotan n "4".
- Naluzotan o "3".
- Naluzotan pubchem "11430856".
- Naluzotan routesOfAdministration Mouth.
- Naluzotan s "1".
- Naluzotan smiles "O=CC".
- Naluzotan stdinchi "1".
- Naluzotan stdinchikey "SPWZXWDPAWDKQE-UHFFFAOYSA-N".
- Naluzotan unii "LQ54E5B4EW".
- Naluzotan verifiedrevid "444039968".
- Naluzotan subject Category:5-HT1A_agonists.
- Naluzotan subject Category:Acetanilides.
- Naluzotan subject Category:Antidepressants.
- Naluzotan subject Category:Anxiolytics.
- Naluzotan subject Category:Piperazines.
- Naluzotan subject Category:Sulfonamides.
- Naluzotan type Drug.
- Naluzotan type FunctionalSubstance.
- Naluzotan comment "Naluzotan (INN, USAN; PRX-00023) is a serotonergic drug of the phenylpiperazine class that was under investigation by EPIX Pharmaceuticals Inc for the treatment of generalized anxiety disorder and major depressive disorder. It acts as a selective and potent 5-HT1A receptor partial agonist, readily stimulating prolactin responses, though it has also been found to bind to and activate the σ receptor.".
- Naluzotan label "Naluzotan".
- Naluzotan sameAs m.05zkhx6.
- Naluzotan sameAs Q6961039.
- Naluzotan sameAs Q6961039.
- Naluzotan wasDerivedFrom Naluzotan?oldid=592611349.
- Naluzotan depiction PRX-00023_structure.png.
- Naluzotan isPrimaryTopicOf Naluzotan.
