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- Nemifitide abstract "Nemifitide (INN-00835) is a novel antidepressant drug with a pentapeptide structure similar to that of melanocyte-inhibiting factor (MIF-1) and the amino acid sequence 4-F-Phe-4-OH-Pro-Arg-Gly-Trp-NH2. It is under development by Tetragenex (previously Innapharma, Inc.) for the treatment of major depressive disorder. It has been given to over 430 people over the course of 12 clinical trials throughout a little over the past decade and has reached Phase III studies, but has not yet been approved for marketing in any country.Nemifitide has shown mixed efficacy in alleviating depressive symptoms, but in the cases in which it has worked it has proven to have a rapid onset of action (~5–7 days), few to no side effects, and an excellent safety profile. However, it is inactive orally and must be administered via subcutaneous injection. Remarkably, despite having a very short half-life of only 15–30 minutes, in most or all studies assessing its efficacy nemifitide has been administered merely once daily via the subcutaneous route and yet is effective for depression.The mechanism of action of nemifitide is unclear, but since MIF-1 has been demonstrated to have similar antidepressant effects it may act in an analogous manner. Possibly of interest however is that nemifitide binds to several receptors including 5-HT2A (where it has been shown to act as an antagonist), NPY1, bombesin, and MC4 and MC5, though at only micromolar concentrations. Whether any of these relatively weak actions are of any clinical significance is unclear.".
- Nemifitide atcPrefix "none".
- Nemifitide casNumber "173240-15-8".
- Nemifitide fdaUniiCode "RO19OXA9NG".
- Nemifitide iupacName "(4R)-4-hydroxy-L-prolyl-N5-(diaminomethylidene)-L-ornithylglycyl-N-[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]-L-tryptophanamide".
- Nemifitide pubchem "177265".
- Nemifitide thumbnail Nemifitide.svg?width=300.
- Nemifitide wikiPageID "22758153".
- Nemifitide wikiPageRevisionID "592626174".
- Nemifitide atcPrefix "none".
- Nemifitide c "33".
- Nemifitide casNumber "173240".
- Nemifitide chemspiderid "154356".
- Nemifitide eliminationHalfLife "-1800.0".
- Nemifitide f "1".
- Nemifitide h "43".
- Nemifitide hasPhotoCollection Nemifitide.
- Nemifitide iupacName "-4".
- Nemifitide legalStatus "Non-regulated".
- Nemifitide molecularWeight "694.756".
- Nemifitide n "10".
- Nemifitide o "6".
- Nemifitide pubchem "177265".
- Nemifitide routesOfAdministration Subcutaneous_injection.
- Nemifitide smiles "O=C[C@H]4NC[C@H]C4".
- Nemifitide unii "RO19OXA9NG".
- Nemifitide width "300".
- Nemifitide subject Category:Antidepressants.
- Nemifitide subject Category:Peptides.
- Nemifitide type Abstraction100002137.
- Nemifitide type AliphaticCompound114601294.
- Nemifitide type Amide114724264.
- Nemifitide type Amides.
- Nemifitide type Amine114739004.
- Nemifitide type Amines.
- Nemifitide type AminoAcid114601829.
- Nemifitide type AminoAcids.
- Nemifitide type Chemical114806838.
- Nemifitide type Compound114818238.
- Nemifitide type Material114580897.
- Nemifitide type Matter100020827.
- Nemifitide type MethaneSeries114951377.
- Nemifitide type OrganicCompound114727670.
- Nemifitide type Part113809207.
- Nemifitide type Peptide114743046.
- Nemifitide type Peptides.
- Nemifitide type PhysicalEntity100001930.
- Nemifitide type Relation100031921.
- Nemifitide type Substance100019613.
- Nemifitide type Drug.
- Nemifitide type FunctionalSubstance.
- Nemifitide comment "Nemifitide (INN-00835) is a novel antidepressant drug with a pentapeptide structure similar to that of melanocyte-inhibiting factor (MIF-1) and the amino acid sequence 4-F-Phe-4-OH-Pro-Arg-Gly-Trp-NH2. It is under development by Tetragenex (previously Innapharma, Inc.) for the treatment of major depressive disorder.".
- Nemifitide label "Nemifitide".
- Nemifitide label "Nemifitide".
- Nemifitide sameAs Nemifitide.
- Nemifitide sameAs m.063_8dz.
- Nemifitide sameAs Q3338011.
- Nemifitide sameAs Q3338011.
- Nemifitide sameAs Nemifitide.
- Nemifitide wasDerivedFrom Nemifitide?oldid=592626174.
- Nemifitide depiction Nemifitide.svg.
- Nemifitide isPrimaryTopicOf Nemifitide.