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- Nesfatin-1 abstract "Nesfatin-1 is a naturally occurring protein molecule produced by the brains of mammals. It is responsible for regulating appetite and production of body fat. Excess nesfatin-1 in the brain leads to a loss of appetite, less frequent hunger, a 'sense of fullness', and a drop in body fat and weight. A lack of nesfatin-1 in the brain leads to an increase of appetite, more frequent episodes of hunger, an increase of body fat and weight, and the inability to 'feel full.' The opposite condition can be artificially induced by injecting an anti-nesfatin-1 antibody into the brain. Dr. Suraj Unniappan, Associate Professor at University of Saskatchewan's Western College of Veterinary Medicine, has studied the metabolic effects of nesfatin-1 in the brains of mammals. His studies found that rats administered with nesfatin-1 ate less, used more stored fat and became more active. Nesfatin-1-induced inhibition of feeding may be mediated through the inhibition of anorexigenic neurons. In addition, the protein stimulated insulin secretion from the pancreatic beta cells of both rats and mice.The receptors within the brain are not completely understood, although they are thought to be contained in the hypothalamus and also in the solitary nucleus, where nesfatin-1 is believed to be produced via peroxisome proliferator-activated receptors (PPARs).Through observation, it appears there is some unknown relationship between nesfatin-1 and cannaboid receptors; however, its precise mechanism and effect remains controversial.[citation needed]Nesfatin-1 was discovered in 2006 by Japanese scientists. The discovery was assisted by Hiroyuki Shimizu at Gunma University Graduate School of Medicine within the Medicine and Molecular Science Department with assistance by research conducted at Saitama University (Saitama, Japan) and the Nippon Medical College (Tokyo, Japan).".
- Nesfatin-1 wikiPageExternalLink signal.jsp?jreq=btjnews&id=20032586&pg_nm=16&sai1=0&new1=0&news1=1A.
- Nesfatin-1 wikiPageExternalLink search=%22nesfatin-1%22.
- Nesfatin-1 wikiPageID "7247837".
- Nesfatin-1 wikiPageRevisionID "600973459".
- Nesfatin-1 hasPhotoCollection Nesfatin-1.
- Nesfatin-1 subject Category:Molecular_biology.
- Nesfatin-1 subject Category:Nutrition.
- Nesfatin-1 subject Category:Proteins.
- Nesfatin-1 subject Category:Proteomics.
- Nesfatin-1 comment "Nesfatin-1 is a naturally occurring protein molecule produced by the brains of mammals. It is responsible for regulating appetite and production of body fat. Excess nesfatin-1 in the brain leads to a loss of appetite, less frequent hunger, a 'sense of fullness', and a drop in body fat and weight.".
- Nesfatin-1 label "Nesfatin-1".
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- Nesfatin-1 sameAs Q6997246.
- Nesfatin-1 sameAs Q6997246.
- Nesfatin-1 wasDerivedFrom Nesfatin-1?oldid=600973459.
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