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- Niaprazine abstract "Niaprazine (Nopron) is a sedative-hypnotic drug of the phenylpiperazine class. It has been used in the treatment of sleep disturbances since the early 1970s in several European countries, including France, Italy, and Luxembourg. It is commonly used with children and adolescents on account of its favorable safety and tolerability profile and lack of abuse potential.Originally believed to act as an antihistamine and anticholinergic, niaprazine was later discovered to have no significant binding affinity for either the H1 or the mACh receptors (Ki = > 1 μM), and was instead found to act as a potent and selective 5-HT2A and α1-adrenergic receptor antagonist (Ki = 75 nM and 86 nM, respectively). It is virtually inactive at 5-HT1A, 5-HT2B, D2, and β-adrenergic, as well as at SERT and VMAT (Ki = all > 1 μM), but it does have some weak affinity for the α2-adrenergic receptor (Ki = 730 nM), likely acting as an antagonist there as well.Niaprazine has been shown to metabolize to the compound pFPP in a similar manner to how trazodone and nefazodone metabolize to mCPP. It is unclear what role, if any, pFPP plays in the clinical effects of niaprazine. However, from animal studies it is known that pFPP, unlike niaprazine, does not produce sedative effects, and instead exerts a behavioral profile indicative of serotonergic activation.".
- Niaprazine atcPrefix "N05".
- Niaprazine atcSuffix "CM16".
- Niaprazine casNumber "27367-90-4".
- Niaprazine fdaUniiCode "R2H3YN6E3L".
- Niaprazine iupacName "N-{4-[4-(4-fluorophenyl)piperazin- 1-yl]butan- 2-yl}pyridine- 3-carboxamide".
- Niaprazine pubchem "71919".
- Niaprazine thumbnail Niaprazine.svg?width=300.
- Niaprazine wikiPageID "9123837".
- Niaprazine wikiPageRevisionID "592646510".
- Niaprazine atcPrefix "N05".
- Niaprazine atcSuffix "CM16".
- Niaprazine c "20".
- Niaprazine casNumber "27367".
- Niaprazine chemspiderid "64930".
- Niaprazine eliminationHalfLife "16200.0".
- Niaprazine f "1".
- Niaprazine h "25".
- Niaprazine hasPhotoCollection Niaprazine.
- Niaprazine iupacName "N-{4-[4-piperazin- 1-yl]butan- 2-yl}pyridine- 3-carboxamide".
- Niaprazine kegg "D07333".
- Niaprazine legalStatus "Rx-only".
- Niaprazine molecularWeight "356.437".
- Niaprazine n "4".
- Niaprazine o "1".
- Niaprazine pubchem "71919".
- Niaprazine routesOfAdministration "Oral".
- Niaprazine smiles "Fc3ccccc3".
- Niaprazine unii "R2H3YN6E3L".
- Niaprazine subject Category:Carboxamides.
- Niaprazine subject Category:Organofluorides.
- Niaprazine subject Category:Piperazines.
- Niaprazine subject Category:Pyridines.
- Niaprazine type Abstraction100002137.
- Niaprazine type Base114618253.
- Niaprazine type Chemical114806838.
- Niaprazine type Compound114818238.
- Niaprazine type Material114580897.
- Niaprazine type Matter100020827.
- Niaprazine type Part113809207.
- Niaprazine type PhysicalEntity100001930.
- Niaprazine type Pyridine114692510.
- Niaprazine type Pyridines.
- Niaprazine type Relation100031921.
- Niaprazine type Substance100019613.
- Niaprazine type Drug.
- Niaprazine type DrugProduct.
- Niaprazine type FunctionalSubstance.
- Niaprazine comment "Niaprazine (Nopron) is a sedative-hypnotic drug of the phenylpiperazine class. It has been used in the treatment of sleep disturbances since the early 1970s in several European countries, including France, Italy, and Luxembourg.".
- Niaprazine label "Niaprazina".
- Niaprazine label "Niaprazine".
- Niaprazine label "Niaprazine".
- Niaprazine sameAs Niaprazine.
- Niaprazine sameAs Niaprazina.
- Niaprazine sameAs m.027yjb5.
- Niaprazine sameAs Q631457.
- Niaprazine sameAs Q631457.
- Niaprazine sameAs Niaprazine.
- Niaprazine wasDerivedFrom Niaprazine?oldid=592646510.
- Niaprazine depiction Niaprazine.svg.
- Niaprazine isPrimaryTopicOf Niaprazine.