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- Non-homologous_end_joining abstract "Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. The term "non-homologous end joining" was coined in 1996 by Moore and Haber.NHEJ typically utilizes short homologous DNA sequences called microhomologies to guide repair. These microhomologies are often present in single-stranded overhangs on the ends of double-strand breaks. When the overhangs are perfectly compatible, NHEJ usually repairs the break accurately. Imprecise repair leading to loss of nucleotides can also occur, but is much more common when the overhangs are not compatible. Inappropriate NHEJ can lead to translocations and telomere fusion, hallmarks of tumor cells.NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells. In budding yeast (Saccharomyces cerevisiae), however, homologous recombination dominates when the organism is grown under common laboratory conditions.When the NHEJ pathway is inactivated, double-strand breaks can be repaired by a more error-prone pathway called microhomology-mediated end joining (MMEJ). In this pathway, end resection reveals short microhomologies on either side of the break, which are then aligned to guide repair. This contrasts with classical NHEJ, which typically uses microhomologies already exposed in single-stranded overhangs on the DSB ends. Repair by MMEJ therefore leads to deletion of the DNA sequence between the microhomologies.".
- Non-homologous_end_joining wikiPageID "1300341".
- Non-homologous_end_joining wikiPageRevisionID "597681058".
- Non-homologous_end_joining hasPhotoCollection Non-homologous_end_joining.
- Non-homologous_end_joining subject Category:DNA_repair.
- Non-homologous_end_joining subject Category:Telomeres.
- Non-homologous_end_joining comment "Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. The term "non-homologous end joining" was coined in 1996 by Moore and Haber.NHEJ typically utilizes short homologous DNA sequences called microhomologies to guide repair.".
- Non-homologous_end_joining label "Naprawa poprzez scalanie niehomologicznych końców DNA".
- Non-homologous_end_joining label "Non-homologous end joining".
- Non-homologous_end_joining label "Recombinación no homóloga".
- Non-homologous_end_joining label "非同源性末端接合".
- Non-homologous_end_joining label "非相同末端結合".
- Non-homologous_end_joining sameAs Recombinación_no_homóloga.
- Non-homologous_end_joining sameAs Jonction_d'extrémités_non-homologues.
- Non-homologous_end_joining sameAs 非相同末端結合.
- Non-homologous_end_joining sameAs Naprawa_poprzez_scalanie_niehomologicznych_końców_DNA.
- Non-homologous_end_joining sameAs m.04r27c.
- Non-homologous_end_joining sameAs Q2065945.
- Non-homologous_end_joining sameAs Q2065945.
- Non-homologous_end_joining wasDerivedFrom Non-homologous_end_joining?oldid=597681058.
- Non-homologous_end_joining isPrimaryTopicOf Non-homologous_end_joining.