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- Norpethidine abstract "Norpethidine (Normeperidine, Pethidine Intermediate B) is a 4-phenylpiperidine derivative that is both a metabolite of and a precursor to pethidine (meperidine). It is scheduled by UN Single Convention on Narcotic Drugs.Norpethidine is a controlled drug because of its potential uses in manufacturing both pethidine itself and a range of N-substituted derivatives, but it has little opioid activity in its own right. Instead, norpethidine acts as a stimulant and causes convulsions.Build up of norpethidine is a major complication when pethidine is used in medicine as an analgesic, as when pethidine is used in high doses or administered by intravenous infusion, norpethidine can accumulate in the body at a faster rate than it is being excreted, particularly in elderly patients or those with compromised liver or kidney function, resulting in a range of toxic effects, mainly convulsions, but also myoclonus and hyponatremia. These complications can be serious and have sometimes resulted in death.Metabolism of pethidine to norpethidine is carried out mainly by the CYP enzymes, CYP2B6, CYP2C19 and CYP3A4, in the liver, and since the activity of these enzymes can vary between individuals and can be influenced by concurrent use of other drugs, the rate and extent of norpethidine production can be difficult to predict.".
- Norpethidine atcPrefix "none".
- Norpethidine casNumber "77-17-8".
- Norpethidine iupacName "ethyl 4-phenylpiperidine-4-carboxylate".
- Norpethidine pubchem "32414".
- Norpethidine thumbnail Norpethidine2DACS.svg?width=300.
- Norpethidine wikiPageID "13994200".
- Norpethidine wikiPageRevisionID "605076680".
- Norpethidine atcPrefix "none".
- Norpethidine c "14".
- Norpethidine casNumber "77".
- Norpethidine chembl "1052".
- Norpethidine chemspiderid "30039".
- Norpethidine h "19".
- Norpethidine hasPhotoCollection Norpethidine.
- Norpethidine image "Norpethidine_27feb.gif".
- Norpethidine inchi "1".
- Norpethidine inchikey "QKHMFBKXTNQCTM-UHFFFAOYAM".
- Norpethidine iupacName "ethyl 4-phenylpiperidine-4-carboxylate".
- Norpethidine legalAu "Unscheduled".
- Norpethidine legalUn "N I".
- Norpethidine legalUs "Schedule II".
- Norpethidine molecularWeight "233.31".
- Norpethidine n "1".
- Norpethidine o "2".
- Norpethidine pubchem "32414".
- Norpethidine routesOfAdministration "N/A".
- Norpethidine smiles "O=CC2CCNCC2".
- Norpethidine stdinchi "1".
- Norpethidine stdinchikey "QKHMFBKXTNQCTM-UHFFFAOYSA-N".
- Norpethidine verifiedrevid "421099421".
- Norpethidine width "190".
- Norpethidine subject Category:Carboxylate_esters.
- Norpethidine subject Category:Ethyl_esters.
- Norpethidine subject Category:Opioid_metabolites.
- Norpethidine subject Category:Piperidines.
- Norpethidine subject Category:Synthetic_opioids.
- Norpethidine type Abstraction100002137.
- Norpethidine type CarboxylateEsters.
- Norpethidine type Chemical114806838.
- Norpethidine type Compound114818238.
- Norpethidine type Ester114850483.
- Norpethidine type EthylEsters.
- Norpethidine type Material114580897.
- Norpethidine type Matter100020827.
- Norpethidine type OrganicCompound114727670.
- Norpethidine type Part113809207.
- Norpethidine type PhysicalEntity100001930.
- Norpethidine type Relation100031921.
- Norpethidine type Substance100019613.
- Norpethidine type Drug.
- Norpethidine type DrugProduct.
- Norpethidine type FunctionalSubstance.
- Norpethidine comment "Norpethidine (Normeperidine, Pethidine Intermediate B) is a 4-phenylpiperidine derivative that is both a metabolite of and a precursor to pethidine (meperidine). It is scheduled by UN Single Convention on Narcotic Drugs.Norpethidine is a controlled drug because of its potential uses in manufacturing both pethidine itself and a range of N-substituted derivatives, but it has little opioid activity in its own right.".
- Norpethidine label "Norpethidine".
- Norpethidine label "Norpetydyna".
- Norpethidine sameAs Norpetydyna.
- Norpethidine sameAs m.03cqg79.
- Norpethidine sameAs Q7053200.
- Norpethidine sameAs Q7053200.
- Norpethidine sameAs Norpethidine.
- Norpethidine wasDerivedFrom Norpethidine?oldid=605076680.
- Norpethidine depiction Norpethidine2DACS.svg.
- Norpethidine isPrimaryTopicOf Norpethidine.