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- Norpropoxyphene abstract "Norpropoxyphene is a major metabolite of the opioid analgesic drug dextropropoxyphene, and is responsible for many of the side effects associated with use of this drug, especially the unusual toxicity seen during dextropropoxyphene overdose. It has weaker analgesic effects than dextropropoxyphene itself, but is a relatively potent pro-convulsant and blocker of sodium and potassium channels, particularly in heart tissue, which produces prolonged intracardiac conduction time and can lead to heart failure following even relatively minor overdoses. The toxicity of this metabolite makes dextropropoxyphene up to 10 times more likely to cause death following overdose compared to other similar mild opioid analgesics, and has led to dextropropoxyphene being withdrawn from the market in some countries.Because norpropoxyphene has a long half-life in the body of up to 36 hours (compared to around 6–12 hours for dextropropoxyphene), it can accumulate in tissues during chronic use of dextropropoxyphene-containing medications, especially in people whose excretion of drugs is slower than normal such as young children, the elderly, and individuals with reduced kidney or liver function, and so side effects including serious adverse events are more common in these groups and use of dextropropoxyphene should be avoided where possible.".
- Norpropoxyphene iupacName "[(2R,3R)-3-methyl-4-(methylamino)-1,2-di(phenyl)butan-2-yl] propanoate".
- Norpropoxyphene thumbnail Norpropoxyphene.png?width=300.
- Norpropoxyphene wikiPageID "22215967".
- Norpropoxyphene wikiPageRevisionID "545615401".
- Norpropoxyphene hasPhotoCollection Norpropoxyphene.
- Norpropoxyphene imagefile "Norpropoxyphene.png".
- Norpropoxyphene iupacname "[-3-methyl-4--1,2-dibutan-2-yl] propanoate".
- Norpropoxyphene verifiedrevid "444029105".
- Norpropoxyphene subject Category:Amines.
- Norpropoxyphene subject Category:Opioid_metabolites.
- Norpropoxyphene subject Category:Propionates.
- Norpropoxyphene subject Category:Synthetic_opioids.
- Norpropoxyphene type Abstraction100002137.
- Norpropoxyphene type AliphaticCompound114601294.
- Norpropoxyphene type Amine114739004.
- Norpropoxyphene type Amines.
- Norpropoxyphene type Chemical114806838.
- Norpropoxyphene type Compound114818238.
- Norpropoxyphene type Material114580897.
- Norpropoxyphene type Matter100020827.
- Norpropoxyphene type MethaneSeries114951377.
- Norpropoxyphene type OrganicCompound114727670.
- Norpropoxyphene type Part113809207.
- Norpropoxyphene type PhysicalEntity100001930.
- Norpropoxyphene type Relation100031921.
- Norpropoxyphene type Substance100019613.
- Norpropoxyphene type ChemicalCompound.
- Norpropoxyphene type ChemicalSubstance.
- Norpropoxyphene type ChemicalSubstanceType.
- Norpropoxyphene type ChemicalObject.
- Norpropoxyphene type Thing.
- Norpropoxyphene comment "Norpropoxyphene is a major metabolite of the opioid analgesic drug dextropropoxyphene, and is responsible for many of the side effects associated with use of this drug, especially the unusual toxicity seen during dextropropoxyphene overdose.".
- Norpropoxyphene label "Norpropoxyphene".
- Norpropoxyphene sameAs m.05q3wkp.
- Norpropoxyphene sameAs Q7053207.
- Norpropoxyphene sameAs Q7053207.
- Norpropoxyphene sameAs Norpropoxyphene.
- Norpropoxyphene wasDerivedFrom Norpropoxyphene?oldid=545615401.
- Norpropoxyphene depiction Norpropoxyphene.png.
- Norpropoxyphene isPrimaryTopicOf Norpropoxyphene.
