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- P14arf abstract "p14ARF is an alternate reading frame (ARF) product of the CDKN2A locus. Both p16INK4a and p14ARF are involved in cell cycle regulation. p14ARF inhibits mdm2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the G1/S checkpoint of the cell cycle. Loss of p14ARF by a homozygous mutation in the CDKN2A (INK4A) gene will lead to elevated levels in mdm2 and, therefore, loss of p53 function and cell cycle control.The equivalent in mice is p19ARF.".
- P14arf arm "p".
- P14arf band "21".
- P14arf chromosome "9".
- P14arf entrezgene "1029".
- P14arf hgncid "1787".
- P14arf omim "600160".
- P14arf refseq "NM_000077".
- P14arf symbol "CDKN2, MLM".
- P14arf symbol "CDKN2A".
- P14arf uniprot "P42771".
- P14arf wikiPageID "6766548".
- P14arf wikiPageRevisionID "589703347".
- P14arf altsymbols "CDKN2, MLM".
- P14arf arm "p".
- P14arf band "21".
- P14arf chromosome "9".
- P14arf entrezgene "1029".
- P14arf hasPhotoCollection P14arf.
- P14arf hgncid "1787".
- P14arf name "cyclin-dependent kinase inhibitor 2A".
- P14arf omim "600160".
- P14arf refseq "NM_000077".
- P14arf symbol "CDKN2A".
- P14arf uniprot "P42771".
- P14arf subject Category:Human_genes.
- P14arf type Biomolecule.
- P14arf type Protein.
- P14arf type ProteinMolecule.
- P14arf type BiologicalObject.
- P14arf comment "p14ARF is an alternate reading frame (ARF) product of the CDKN2A locus. Both p16INK4a and p14ARF are involved in cell cycle regulation. p14ARF inhibits mdm2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the G1/S checkpoint of the cell cycle.".
- P14arf label "P14arf".
- P14arf sameAs m.0gmv71.
- P14arf sameAs Q7117832.
- P14arf sameAs Q7117832.
- P14arf wasDerivedFrom P14arf?oldid=589703347.
- P14arf isPrimaryTopicOf P14arf.
- P14arf name "cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)".