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- PEN-2 abstract "PEN-2 (presenilin enhancer 2) is a protein that is a regulatory component of the gamma secretase complex, a protease complex responsible for proteolysis of transmembrane proteins such as the Notch protein and amyloid precursor protein (APP). The gamma secretase complex consists of PEN-2, APH-1, nicastrin, and the catalytic subunit presenilin. PEN-2 is a 101-amino acid integral membrane protein likely with a topology such that both the N-terminus and the C-terminus face first the lumen of the endoplasmic reticulum and later the extracellular environment. Biochemical studies have shown that a conserved sequence motif D-Y-L-S-F at the C-terminus, as well as the overall length of the C-terminal tail, is required for the formation of an active gamma secretase complex.".
- PEN-2 arm "q".
- PEN-2 band "13.12".
- PEN-2 chromosome "19".
- PEN-2 entrezgene "55851".
- PEN-2 hgncid "30100".
- PEN-2 omim "607632".
- PEN-2 refseq "NM_172341".
- PEN-2 symbol "PSENEN".
- PEN-2 uniprot "Q9NZ42".
- PEN-2 wikiPageID "10026350".
- PEN-2 wikiPageRevisionID "487043682".
- PEN-2 arm "q".
- PEN-2 band "13.12".
- PEN-2 chromosome "19".
- PEN-2 entrezgene "55851".
- PEN-2 hasPhotoCollection PEN-2.
- PEN-2 hgncid "30100".
- PEN-2 name "presenilin enhancer 2 homolog".
- PEN-2 omim "607632".
- PEN-2 refseq "NM_172341".
- PEN-2 symbol "PSENEN".
- PEN-2 uniprot "Q9NZ42".
- PEN-2 subject Category:Alzheimer's_disease.
- PEN-2 subject Category:Proteins.
- PEN-2 type Biomolecule.
- PEN-2 type Protein.
- PEN-2 type ProteinMolecule.
- PEN-2 type BiologicalObject.
- PEN-2 comment "PEN-2 (presenilin enhancer 2) is a protein that is a regulatory component of the gamma secretase complex, a protease complex responsible for proteolysis of transmembrane proteins such as the Notch protein and amyloid precursor protein (APP). The gamma secretase complex consists of PEN-2, APH-1, nicastrin, and the catalytic subunit presenilin.".
- PEN-2 label "PEN-2".
- PEN-2 sameAs m.02p_7b0.
- PEN-2 sameAs Q7118948.
- PEN-2 sameAs Q7118948.
- PEN-2 wasDerivedFrom PEN-2?oldid=487043682.
- PEN-2 isPrimaryTopicOf PEN-2.
- PEN-2 name "presenilin enhancer 2 homolog (C. elegans)".