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- PEPAP abstract "PEPAP is an opioid analgesic that is an analog of pethidine (meperidine). It is related to the drug MPPP, with an N-phenethyl group in place of the N-methyl substitution and an acetate ester rather than propionate. PEPAP is approximately 6-7 times more potent than morphine in laboratory rats. PEPAP presumably has similar effects to other opioids, producing analgesia, sedation and euphoria. Side effects can include itching, nausea and potentially serious respiratory depression which can be life-threatening. PEPAP has been found to be a potent CYP2D6 inhibitor, which makes it likely to cause adverse interactions with some other drugs, although the inhibitory potency of PEPAP is less than that of MPPP. (Both cocaine and methadone are also CYP2D6 inhibitors and could, in theory, potentiate the effect.) It is unlikely that the tetrahydropyridine byproducts that may be formed during the synthesis of PEPAP are neurotoxic in the same way as the MPPP byproduct MPTP. It appears that the N-methyl group of MPTP is required for neurotoxic activity. In animal experiments, only MPTP analogues that preserved the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine structure were active as dopaminergic neurotoxins. Most structural changes, including replacing the N-methyl group with other substituents, abolished neurotoxicity.There is evidence that the clandestine manufacturers who produced MPPP in the 1970s (included the tainted batch) went on to produce PEPAP in an attempt to avoid using watched precursors or drug intermediates that were illegal.".
- PEPAP casNumber "64-52-8".
- PEPAP drugbank "DB01562".
- PEPAP iupacName "4-phenyl-1-(2-phenylethyl)piperidin-4-yl acetate".
- PEPAP pubchem "60977".
- PEPAP thumbnail PEPAP.svg?width=300.
- PEPAP wikiPageID "14031629".
- PEPAP wikiPageRevisionID "547672898".
- PEPAP c "21".
- PEPAP casNumber "64".
- PEPAP chemspiderid "54939".
- PEPAP drugbank "DB01562".
- PEPAP h "25".
- PEPAP hasPhotoCollection PEPAP.
- PEPAP inchi "1".
- PEPAP inchikey "BVURVTVDNWSNFN-UHFFFAOYAG".
- PEPAP iupacName "4".
- PEPAP legalUk "Class A".
- PEPAP legalUs "Schedule I".
- PEPAP molecularWeight "323.43".
- PEPAP n "1".
- PEPAP o "2".
- PEPAP pubchem "60977".
- PEPAP smiles "O=COC1C3=CC=CC=C3".
- PEPAP stdinchi "1".
- PEPAP stdinchikey "BVURVTVDNWSNFN-UHFFFAOYSA-N".
- PEPAP synonyms "PEPAP".
- PEPAP verifiedrevid "447994304".
- PEPAP width "160".
- PEPAP subject Category:Acetate_esters.
- PEPAP subject Category:Mu-opioid_agonists.
- PEPAP subject Category:Piperidines.
- PEPAP subject Category:Synthetic_opioids.
- PEPAP type Abstraction100002137.
- PEPAP type AcetateEsters.
- PEPAP type Chemical114806838.
- PEPAP type Compound114818238.
- PEPAP type Ester114850483.
- PEPAP type Material114580897.
- PEPAP type Matter100020827.
- PEPAP type OrganicCompound114727670.
- PEPAP type Part113809207.
- PEPAP type PhysicalEntity100001930.
- PEPAP type Relation100031921.
- PEPAP type Substance100019613.
- PEPAP type Drug.
- PEPAP type DrugProduct.
- PEPAP type FunctionalSubstance.
- PEPAP comment "PEPAP is an opioid analgesic that is an analog of pethidine (meperidine). It is related to the drug MPPP, with an N-phenethyl group in place of the N-methyl substitution and an acetate ester rather than propionate. PEPAP is approximately 6-7 times more potent than morphine in laboratory rats. PEPAP presumably has similar effects to other opioids, producing analgesia, sedation and euphoria.".
- PEPAP label "PEPAP".
- PEPAP label "PEPAP".
- PEPAP sameAs PEPAP.
- PEPAP sameAs m.03crkg6.
- PEPAP sameAs Q7118988.
- PEPAP sameAs Q7118988.
- PEPAP sameAs PEPAP.
- PEPAP wasDerivedFrom PEPAP?oldid=547672898.
- PEPAP depiction PEPAP.svg.
- PEPAP isPrimaryTopicOf PEPAP.