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- PF-4840154 abstract "PF-4840154 is pyrimidine derivative discovered by Pfizer at its Sandwich, Kent research centre. The compound is a potent, selective activator of both the human (EC50 = 23 nM) and rat (EC50 = 97 nM) TRPA1 channels. This compound elicits nociception in a mouse model through TRPA1 activation. PF-4840154 is used as a reference agonist of the TRPA1 channel for in-vitro High-throughput screening purposes, and is superior to allyl isothiocyanate for this use. The TRPA1 channel is considered an attractive pain target based on the fact that TRPA1 knockout mice showed near complete attenuation of pain behaviours in some pre-clinical development models.".
- PF-4840154 iupacName "4-Isobutylamino-2-[4-(tetrahydro-pyran-3-ylmethyl)-piperazin-1-yl]-pyrimidine-5-carboxylic acid benzylamide".
- PF-4840154 thumbnail PF-4840154.svg?width=300.
- PF-4840154 wikiPageID "32478452".
- PF-4840154 wikiPageRevisionID "592772850".
- PF-4840154 hasPhotoCollection PF-4840154.
- PF-4840154 imagefile "PF-4840154.svg".
- PF-4840154 imagesize "200".
- PF-4840154 iupacname "4".
- PF-4840154 verifiedfields "changed".
- PF-4840154 verifiedrevid "442500296".
- PF-4840154 subject Category:Ion_channels.
- PF-4840154 subject Category:Pfizer.
- PF-4840154 subject Category:Piperazines.
- PF-4840154 subject Category:Pyrans.
- PF-4840154 subject Category:Pyrimidines.
- PF-4840154 subject Category:Receptor_agonists.
- PF-4840154 type ChemicalCompound.
- PF-4840154 type ChemicalSubstance.
- PF-4840154 type ChemicalObject.
- PF-4840154 type Thing.
- PF-4840154 comment "PF-4840154 is pyrimidine derivative discovered by Pfizer at its Sandwich, Kent research centre. The compound is a potent, selective activator of both the human (EC50 = 23 nM) and rat (EC50 = 97 nM) TRPA1 channels. This compound elicits nociception in a mouse model through TRPA1 activation. PF-4840154 is used as a reference agonist of the TRPA1 channel for in-vitro High-throughput screening purposes, and is superior to allyl isothiocyanate for this use.".
- PF-4840154 label "PF-4840154".
- PF-4840154 sameAs m.0h1h4xk.
- PF-4840154 sameAs Q7119050.
- PF-4840154 sameAs Q7119050.
- PF-4840154 wasDerivedFrom PF-4840154?oldid=592772850.
- PF-4840154 depiction PF-4840154.svg.
- PF-4840154 isPrimaryTopicOf PF-4840154.