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- PRC200 abstract "PRC200-SS is an arylalkanolamine TRI being developed by the Mayo Clinic. Sympathomimetic PRC200-SS is the PRC050 eutomer, whereas PRC201 is the distomer. These compounds are preceded by venlafaxine, which Wyeth claims is the first SNRI. Venlafaxine was originally developed as an "opioid" although original screening returned negative results. The authors were not satisfied just to drop venlafaxine from development and continued with their study of the compounds biological activity data. Herein, they discovered that venlafaxine exerts its biological actions via interaction with the monoamine receptors. In particular, the actions of the drug on increasing the amount of 5-HT and NE were documented, although with "potentiated" analogs such as the pm-dichlorophenyl ring substituted derivative, it might be expected to behave as a SNDRI also (but no data was available to support this inference). Venlafaxine itself has been said to behave as a SNDRI at very high doses. This would be more likely to be the case in drug naїve subjects than in users that have already built up significant tolerance.Silicon containing analog of venlafaxine was prepared and demonstrated to be an active SNRI.".
- PRC200 iupacName "(1S,2S)-3-(methylamino)-2-naphthalen-2-yl-1-phenylpropan-1-ol".
- PRC200 pubchem "20631904".
- PRC200 thumbnail PRC200_structure.png?width=300.
- PRC200 wikiPageID "23928336".
- PRC200 wikiPageRevisionID "592842878".
- PRC200 c "20".
- PRC200 chemspiderid "19318181".
- PRC200 h "21".
- PRC200 hasPhotoCollection PRC200.
- PRC200 inchi "1".
- PRC200 inchikey "RSZGIFQDUIROGN-WOJBJXKFBB".
- PRC200 iupacName "-3".
- PRC200 molecularWeight "291.386".
- PRC200 n "1".
- PRC200 o "1".
- PRC200 pubchem "20631904".
- PRC200 smiles "O[C@H][C@H]c2cc3ccccc3cc2".
- PRC200 stdinchi "1".
- PRC200 stdinchikey "RSZGIFQDUIROGN-WOJBJXKFSA-N".
- PRC200 verifiedfields "changed".
- PRC200 verifiedrevid "451223794".
- PRC200 watchedfields "changed".
- PRC200 subject Category:Alcohols.
- PRC200 subject Category:Amines.
- PRC200 subject Category:Naphthalenes.
- PRC200 subject Category:Serotonin-norepinephrine-dopamine_reuptake_inhibitors.
- PRC200 type Drug.
- PRC200 type DrugProduct.
- PRC200 type FunctionalSubstance.
- PRC200 comment "PRC200-SS is an arylalkanolamine TRI being developed by the Mayo Clinic. Sympathomimetic PRC200-SS is the PRC050 eutomer, whereas PRC201 is the distomer. These compounds are preceded by venlafaxine, which Wyeth claims is the first SNRI. Venlafaxine was originally developed as an "opioid" although original screening returned negative results. The authors were not satisfied just to drop venlafaxine from development and continued with their study of the compounds biological activity data.".
- PRC200 label "PRC200".
- PRC200 sameAs m.076zhnx.
- PRC200 sameAs Q7120261.
- PRC200 sameAs Q7120261.
- PRC200 wasDerivedFrom PRC200?oldid=592842878.
- PRC200 depiction PRC200_structure.png.
- PRC200 isPrimaryTopicOf PRC200.