Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Paclitaxel> ?p ?o. }
- Paclitaxel abstract "Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a US National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol. Later it was discovered that endophytic fungi in the bark synthesize paclitaxel.When it was developed commercially by Bristol-Myers Squibb (BMS), the generic name was changed to paclitaxel and the BMS compound is sold under the trademark Taxol. In this formulation, paclitaxel is dissolved in Kolliphor EL and ethanol, as a delivery agent. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane.Paclitaxel is used to treat patients with lung, ovarian, breast, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is also used for the prevention of restenosis.Paclitaxel stabilizes microtubules and, as a result, interferes with the normal breakdown of microtubules during cell division. Together with docetaxel, it forms the drug category of the taxanes. It was the subject of a notable total synthesis by Robert A. Holton of Florida State University.While offering substantial improvement in patient care, paclitaxel has been a relatively controversial drug. There was originally concern because of the environmental impact of its original sourcing (no longer used) from the Pacific yew. In addition, the assignment of rights to Bristol-Myers Squibb and even the name itself were the subject of public debate and Congressional hearings. Clinicians sometimes use the abbreviation "PTX" for paclitaxel, although (like many medical abbreviations) it is not a unique identifier. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.".
- Paclitaxel atcPrefix "L01".
- Paclitaxel atcSuffix "CD01".
- Paclitaxel atcSupplemental "(paclitaxel poliglumex)".
- Paclitaxel bioavailability "6.5".
- Paclitaxel casNumber "33069-62-4".
- Paclitaxel chEBI "45863".
- Paclitaxel drugbank "DB01229".
- Paclitaxel fdaUniiCode "P88XT4IS4D".
- Paclitaxel iupacName "(2α,4α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-13-{[(2R,3S)- 3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}- 1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate".
- Paclitaxel pubchem "36314".
- Paclitaxel thumbnail Taxol.svg?width=300.
- Paclitaxel wikiPageExternalLink dpdirect.jsp?name=Paclitaxel.
- Paclitaxel wikiPageExternalLink fullpage.html?sec=health&res=9B0CE1DD1730F932A35753C1A9609C8B63&partner=rssnyt&emc=rss.
- Paclitaxel wikiPageExternalLink taxol2.htm.
- Paclitaxel wikiPageExternalLink drugdictionary.aspx?CdrID=39762.
- Paclitaxel wikiPageExternalLink paclitaxel.
- Paclitaxel wikiPageExternalLink taxol.html.
- Paclitaxel wikiPageID "36796".
- Paclitaxel wikiPageRevisionID "606301350".
- Paclitaxel atcPrefix "L01".
- Paclitaxel atcSuffix "CD01".
- Paclitaxel bioavailability "6.5".
- Paclitaxel c "47".
- Paclitaxel casNumber "33069".
- Paclitaxel chebi "45863".
- Paclitaxel chembl "48".
- Paclitaxel chemspiderid "10368587".
- Paclitaxel drugbank "DB01229".
- Paclitaxel eliminationHalfLife "20880.0".
- Paclitaxel excretion "Fecal and urinary".
- Paclitaxel h "51".
- Paclitaxel hasPhotoCollection Paclitaxel.
- Paclitaxel image "Taxol3D.png".
- Paclitaxel inchi "1".
- Paclitaxel iupacName "-410".
- Paclitaxel iupharLigand "2770".
- Paclitaxel kegg "D00491".
- Paclitaxel legalUs "Rx-only".
- Paclitaxel metabolism "Hepatic".
- Paclitaxel molecularWeight "853.906".
- Paclitaxel n "1".
- Paclitaxel o "14".
- Paclitaxel pdbLigand "TA1".
- Paclitaxel pregnancyUs "D".
- Paclitaxel proteinBound "89".
- Paclitaxel pubchem "36314".
- Paclitaxel routesOfAdministration Intravenous_therapy.
- Paclitaxel smiles "CC1=C2[C@@]C".
- Paclitaxel stdinchi "1".
- Paclitaxel stdinchikey "RCINICONZNJXQF-MZXODVADSA-N".
- Paclitaxel tradename "Abraxane, Taxol".
- Paclitaxel unii "P88XT4IS4D".
- Paclitaxel verifiedfields "changed".
- Paclitaxel verifiedrevid "458461737".
- Paclitaxel width "250".
- Paclitaxel subject Category:Acetate_esters.
- Paclitaxel subject Category:Alcohols.
- Paclitaxel subject Category:Benzamides.
- Paclitaxel subject Category:Benzoates.
- Paclitaxel subject Category:Bristol-Myers_Squibb.
- Paclitaxel subject Category:Ketones.
- Paclitaxel subject Category:Microtubule_inhibitors.
- Paclitaxel subject Category:Mitotic_inhibitors.
- Paclitaxel subject Category:Propionates.
- Paclitaxel subject Category:Taxanes.
- Paclitaxel type Abstraction100002137.
- Paclitaxel type AcetateEsters.
- Paclitaxel type Agent114778436.
- Paclitaxel type Alcohol107884567.
- Paclitaxel type Alcohols.
- Paclitaxel type Alkaloid114712692.
- Paclitaxel type Alkaloids.
- Paclitaxel type Benzoate114775067.
- Paclitaxel type Benzoates.
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- Paclitaxel type CausalAgent100007347.
- Paclitaxel type Chemical114806838.
- Paclitaxel type Compound114818238.
- Paclitaxel type Drug103247620.
- Paclitaxel type DrugOfAbuse103248958.
- Paclitaxel type Ester114850483.
- Paclitaxel type Fluid114939900.
- Paclitaxel type Food100021265.
- Paclitaxel type Ketone114926294.
- Paclitaxel type Ketones.
- Paclitaxel type Liquid114940386.
- Paclitaxel type Material114580897.
- Paclitaxel type Matter100020827.
- Paclitaxel type OrganicCompound114727670.
- Paclitaxel type Part113809207.
- Paclitaxel type PhysicalEntity100001930.
- Paclitaxel type Relation100031921.
- Paclitaxel type Salt115010703.
- Paclitaxel type Substance100019613.
- Paclitaxel type Substance100020090.
- Paclitaxel type Drug.
- Paclitaxel type DrugProduct.
- Paclitaxel type FunctionalSubstance.
- Paclitaxel comment "Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a US National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol.".