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- Paracetamol_toxicity abstract "Paracetamol toxicity is caused by excessive use or overdose of the analgesic drug paracetamol (called acetaminophen in North America). Mainly causing liver injury, paracetamol toxicity is one of the most common causes of poisoning worldwide. In the United States and the United Kingdom it is the most common cause of acute liver failure.Many individuals with paracetamol toxicity may have no symptoms at all in the first 24 hours following overdose. Others may initially have nonspecific complaints such as vague abdominal pain and nausea. With progressive disease, signs of liver failure may develop; these include low blood sugar, low blood pH, easy bleeding, and hepatic encephalopathy. Some will spontaneously resolve, although untreated cases may result in death.Damage to the liver, or hepatotoxicity, results not from paracetamol itself, but from one of its metabolites, N-acetyl-p-benzoquinoneimine (NAPQI)(also known as N-acetylimidoquinone). NAPQI depletes the liver's natural antioxidant glutathione and directly damages cells in the liver, leading to liver failure. Risk factors for toxicity include excessive chronic alcohol intake, fasting or anorexia nervosa, and the use of certain drugs such as isoniazid.Treatment is aimed at removing the paracetamol from the body and replacing glutathione. Activated charcoal can be used to decrease absorption of paracetamol if the patient presents for treatment soon after the overdose; the antidote acetylcysteine acts as a precursor for glutathione, helping the body regenerate enough to prevent damage to the liver. N-acetylcysteine can neutralize NAPQI by itself as well. A liver transplant is often required if damage to the liver becomes severe. Patients treated early have a good prognosis, whereas patients that develop major liver abnormalities typically have a poor outcome. Efforts to prevent paracetamol overdose include limiting individual sales of the drug and combining paracetamol with methionine, which is converted into glutathione in the liver.".
- Paracetamol_toxicity emedicineSubject "ped".
- Paracetamol_toxicity emedicineTopic "7".
- Paracetamol_toxicity icd10 "T39.1".
- Paracetamol_toxicity icd9 "965.4".
- Paracetamol_toxicity medlineplus "002598".
- Paracetamol_toxicity thumbnail Paracetamol-skeletal.svg?width=300.
- Paracetamol_toxicity wikiPageExternalLink tylenol-mcneil-fda-kids-dose-of-confusion.
- Paracetamol_toxicity wikiPageExternalLink tylenol-mcneil-fda-use-only-as-directed.
- Paracetamol_toxicity wikiPageExternalLink use-only-as-directed.
- Paracetamol_toxicity wikiPageID "19690848".
- Paracetamol_toxicity wikiPageRevisionID "606639606".
- Paracetamol_toxicity caption Paracetamol.
- Paracetamol_toxicity emedicinesubj "ped".
- Paracetamol_toxicity emedicinetopic "7".
- Paracetamol_toxicity hasPhotoCollection Paracetamol_toxicity.
- Paracetamol_toxicity icd "965.4".
- Paracetamol_toxicity icd "T39.1".
- Paracetamol_toxicity medlineplus "2598".
- Paracetamol_toxicity name "Paracetamol toxicity".
- Paracetamol_toxicity subject Category:Poisoning_by_drugs,_medicaments_and_biological_substances.
- Paracetamol_toxicity type Abstraction100002137.
- Paracetamol_toxicity type Attribute100024264.
- Paracetamol_toxicity type Condition113920835.
- Paracetamol_toxicity type Disease114070360.
- Paracetamol_toxicity type IllHealth114052046.
- Paracetamol_toxicity type Illness114061805.
- Paracetamol_toxicity type PathologicalState114051917.
- Paracetamol_toxicity type PhysicalCondition114034177.
- Paracetamol_toxicity type State100024720.
- Paracetamol_toxicity type Disease.
- Paracetamol_toxicity type AilmentCondition.
- Paracetamol_toxicity type Situation.
- Paracetamol_toxicity comment "Paracetamol toxicity is caused by excessive use or overdose of the analgesic drug paracetamol (called acetaminophen in North America). Mainly causing liver injury, paracetamol toxicity is one of the most common causes of poisoning worldwide. In the United States and the United Kingdom it is the most common cause of acute liver failure.Many individuals with paracetamol toxicity may have no symptoms at all in the first 24 hours following overdose.".
- Paracetamol_toxicity label "Avvelenamento da paracetamolo".
- Paracetamol_toxicity label "Paracetamol toxicity".
- Paracetamol_toxicity label "Токсичность парацетамола".
- Paracetamol_toxicity label "سمية الباراسيتامول".
- Paracetamol_toxicity sameAs Avvelenamento_da_paracetamolo.
- Paracetamol_toxicity sameAs m.04n5872.
- Paracetamol_toxicity sameAs Q2572879.
- Paracetamol_toxicity sameAs Q2572879.
- Paracetamol_toxicity sameAs Paracetamol_toxicity.
- Paracetamol_toxicity wasDerivedFrom Paracetamol_toxicity?oldid=606639606.
- Paracetamol_toxicity depiction Paracetamol-skeletal.svg.
- Paracetamol_toxicity isPrimaryTopicOf Paracetamol_toxicity.
- Paracetamol_toxicity name "Paracetamol toxicity".