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- Paraneoplastic_cerebellar_degeneration abstract "Paraneoplastic cerebellar degeneration (PCD) is a paraneoplastic syndrome associated with lung, ovarian, breast, Hodgkin’s lymphoma and other cancers. PCD is a rare condition that occurs in less than 1% of cancer patients and usually occurs in middle-aged women. As is the case with other paraneoplastic syndromes, PCD is believed to be due to an autoimmune reaction targeted against components of the central nervous system (in PCD, this is specifically Purkinje cells in the cerebellum, sometimes accompanied by a proliferation of Berg- mann astrocytes and microglia in the molecular layer of the cerebellum and a loss of granule cells ). It is thought to be triggered when tumor cells (in PCD, most commonly ovarian or breast cancer) express a protein normally expressed in the brain (in PCD, this is the Purkinje neuronal protein termed cdr2). This is believed to trigger an anti-tumor immune response that may be clinically significant, but also an anti-neuronal immune response. PCD patients harbor an anti-neuronal antibody known as anti-Yo (named after the first two letters of the index patient). PCD may be associated with onconeural antibodies directed against other intracellular antigens or against cell surface and with other tumors. When associated with small cell lung cancer, it is antibody termed "anti-Hu" (more commonly associated with paraneoplastic subacute sensory neuropathy and/or limbic encephalitis). The immune cells cross the blood–brain barrier, resulting in an autoimmune attack of Purkinje cells throughout the cerebellar cortex. Radiologic imaging occasionally reveals cerebellar atrophy. Other paraneoplastic antibodies may be associated with PCD symptoms, including anti-Tr and antibodies to glutamate receptor. Occasionally myoclonia and opsoclonus may occur.Neurological symptoms present insidiously and progress rapidly for about 6 months to a severely disabled state followed by a variable plateau period that can last for months to years. The clinical cerebellar ataxia evident in patients with PCD are caused by Purkinje neuronal loss in the cerebellum. It is manifested by dysarthria, truncal, limb and gait ataxia, vertigo, nausea, vomiting, diplopia and nystagmus. Neurological symptoms precede the diagnosis of the underlying cancer in about 60% of cases. A cure of the cancer underlying PCD usually does not affect neurological symptoms, as cerebellar dysfunction stabilizes in the early stage after symptom onset before the cancer treatment has been initiated. There may be a role for high dose gammaglobulin therapy in the treatment PCD, but due to the rare occurrence of this disease, controlled trials of this therapy may be difficult.".
- Paraneoplastic_cerebellar_degeneration diseasesdb "33977".
- Paraneoplastic_cerebellar_degeneration emedicineSubject "neuro".
- Paraneoplastic_cerebellar_degeneration emedicineTopic "299".
- Paraneoplastic_cerebellar_degeneration icd10 "G13.0".
- Paraneoplastic_cerebellar_degeneration icd9 "334.9".
- Paraneoplastic_cerebellar_degeneration meshId "D020362".
- Paraneoplastic_cerebellar_degeneration wikiPageExternalLink yo.php.
- Paraneoplastic_cerebellar_degeneration wikiPageID "5788955".
- Paraneoplastic_cerebellar_degeneration wikiPageRevisionID "576950013".
- Paraneoplastic_cerebellar_degeneration diseasesdb "33977".
- Paraneoplastic_cerebellar_degeneration emedicinesubj "neuro".
- Paraneoplastic_cerebellar_degeneration emedicinetopic "299".
- Paraneoplastic_cerebellar_degeneration hasPhotoCollection Paraneoplastic_cerebellar_degeneration.
- Paraneoplastic_cerebellar_degeneration icd "334.9".
- Paraneoplastic_cerebellar_degeneration icd "G13.0".
- Paraneoplastic_cerebellar_degeneration meshid "D020362".
- Paraneoplastic_cerebellar_degeneration name "Paraneoplastic cerebellar degeneration".
- Paraneoplastic_cerebellar_degeneration wordnet_type synset-disease-noun-1.
- Paraneoplastic_cerebellar_degeneration subject Category:Paraneoplastic_syndromes.
- Paraneoplastic_cerebellar_degeneration type Abstraction100002137.
- Paraneoplastic_cerebellar_degeneration type Cognition100023271.
- Paraneoplastic_cerebellar_degeneration type Complex105870365.
- Paraneoplastic_cerebellar_degeneration type Concept105835747.
- Paraneoplastic_cerebellar_degeneration type Content105809192.
- Paraneoplastic_cerebellar_degeneration type Idea105833840.
- Paraneoplastic_cerebellar_degeneration type ParaneoplasticSyndromes.
- Paraneoplastic_cerebellar_degeneration type PsychologicalFeature100023100.
- Paraneoplastic_cerebellar_degeneration type Syndrome105870790.
- Paraneoplastic_cerebellar_degeneration type Whole105869584.
- Paraneoplastic_cerebellar_degeneration type Disease.
- Paraneoplastic_cerebellar_degeneration type AilmentCondition.
- Paraneoplastic_cerebellar_degeneration type Situation.
- Paraneoplastic_cerebellar_degeneration comment "Paraneoplastic cerebellar degeneration (PCD) is a paraneoplastic syndrome associated with lung, ovarian, breast, Hodgkin’s lymphoma and other cancers. PCD is a rare condition that occurs in less than 1% of cancer patients and usually occurs in middle-aged women.".
- Paraneoplastic_cerebellar_degeneration label "Degenerazione cerebrale paraneoplastica".
- Paraneoplastic_cerebellar_degeneration label "Paraneoplastic cerebellar degeneration".
- Paraneoplastic_cerebellar_degeneration label "التحلل المخيخي المصاحب للأورام".
- Paraneoplastic_cerebellar_degeneration sameAs Degenerazione_cerebrale_paraneoplastica.
- Paraneoplastic_cerebellar_degeneration sameAs m.0f4mvj.
- Paraneoplastic_cerebellar_degeneration sameAs Q7135464.
- Paraneoplastic_cerebellar_degeneration sameAs Q7135464.
- Paraneoplastic_cerebellar_degeneration sameAs Paraneoplastic_cerebellar_degeneration.
- Paraneoplastic_cerebellar_degeneration wasDerivedFrom Paraneoplastic_cerebellar_degeneration?oldid=576950013.
- Paraneoplastic_cerebellar_degeneration isPrimaryTopicOf Paraneoplastic_cerebellar_degeneration.
- Paraneoplastic_cerebellar_degeneration name "Paraneoplastic cerebellar degeneration".