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- Pathophysiology_of_multiple_sclerosis abstract "Multiple sclerosis is a condition where the CNS of a person present a special kind of distributed lesions (sclerosis) whose pathophysiology is complex and still under investigation. It is considered a pathological entity by some authors and a clinical entity by some others.The unknown underlying condition causes damage in two phases. First some MRI-abnormal areas with hidden damage appear in the brain and spine (NAWM, NAGM, DAWM), followed later by leaks in the blood–brain barrier where immune cells infiltrate causing the known demyelination.MS is mainly a white matter disease, and lesions appear mainly in a peri-ventricular distribution (lesions clustered around the ventricles of the brain), but apart from the usually known white matter demyelination, also the cortex and deep gray matter (GM) nuclei are affected, together with diffuse injury of the normal-appearing white matter. MS is active even during remission periods. GM atrophy is independent of the MS lesions and is associated with physical disability, fatigue, and cognitive impairment in MSAt least five characteristics are present in CNS tissues of MS patients: Inflammation beyond classical white matter lesions, intrathecal Ig production with oligoclonal bands, an environment fostering immune cell persistence, Follicle-like aggregates in the meninges and a disruption of the blood–brain barrier also outside of active lesions. The scars that give the name to the condition are produced by the astrocyte cells healing old lesions.".
- Pathophysiology_of_multiple_sclerosis thumbnail MS_Demyelinisation_KB_10x.jpg?width=300.
- Pathophysiology_of_multiple_sclerosis wikiPageExternalLink top.
- Pathophysiology_of_multiple_sclerosis wikiPageExternalLink n03switch.htm.
- Pathophysiology_of_multiple_sclerosis wikiPageExternalLink Research-TargetedLesion.asp.
- Pathophysiology_of_multiple_sclerosis wikiPageID "4930095".
- Pathophysiology_of_multiple_sclerosis wikiPageRevisionID "605772353".
- Pathophysiology_of_multiple_sclerosis hasPhotoCollection Pathophysiology_of_multiple_sclerosis.
- Pathophysiology_of_multiple_sclerosis subject Category:Autoimmune_diseases.
- Pathophysiology_of_multiple_sclerosis subject Category:Multiple_sclerosis.
- Pathophysiology_of_multiple_sclerosis subject Category:Neurology.
- Pathophysiology_of_multiple_sclerosis subject Category:Pathophysiology.
- Pathophysiology_of_multiple_sclerosis comment "Multiple sclerosis is a condition where the CNS of a person present a special kind of distributed lesions (sclerosis) whose pathophysiology is complex and still under investigation. It is considered a pathological entity by some authors and a clinical entity by some others.The unknown underlying condition causes damage in two phases.".
- Pathophysiology_of_multiple_sclerosis label "Pathophysiology of multiple sclerosis".
- Pathophysiology_of_multiple_sclerosis sameAs Q12290062.
- Pathophysiology_of_multiple_sclerosis sameAs Q12290062.
- Pathophysiology_of_multiple_sclerosis wasDerivedFrom Pathophysiology_of_multiple_sclerosis?oldid=605772353.
- Pathophysiology_of_multiple_sclerosis depiction MS_Demyelinisation_KB_10x.jpg.
- Pathophysiology_of_multiple_sclerosis isPrimaryTopicOf Pathophysiology_of_multiple_sclerosis.
