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- Perhexiline abstract "Perhexiline (Pexsig) is a prophylactic antianginal agent used primarily in Australia and New Zealand. Perhexiline is thought to act by inhibiting mitochondrial carnitine palmitoyltransferase-1. This shifts myocardial metabolism from fatty acid to glucose utilisation which results in increased ATP production for the same O2 consumption and consequently increases myocardial efficiency. Its clinical use has been limited by its narrow therapeutic index and high inter- and intra-individual pharmacokinetic variability. It was outlawed in many countries due to its adverse effects on poor metabolisers (PM). The product has been reintroduced for patients who have contraindications, or have not responded to, other treatments for angina.".
- Perhexiline atcPrefix "C08".
- Perhexiline atcSuffix "EX02".
- Perhexiline casNumber "6621-47-2".
- Perhexiline chEBI "35553".
- Perhexiline drugbank "DB01074".
- Perhexiline fdaUniiCode "KU65374X44".
- Perhexiline iupacName "2-(2,2-dicyclohexylethyl)piperidine".
- Perhexiline pubchem "4746".
- Perhexiline thumbnail Perhexiline_structure.svg?width=300.
- Perhexiline wikiPageID "3054011".
- Perhexiline wikiPageRevisionID "573736358".
- Perhexiline atcPrefix "8.0".
- Perhexiline atcSuffix "EX02".
- Perhexiline bioavailability "Dose Dependent".
- Perhexiline c "19".
- Perhexiline casNumber "6621".
- Perhexiline chebi "35553".
- Perhexiline chembl "75880".
- Perhexiline chemspiderid "4584".
- Perhexiline drugbank "DB01074".
- Perhexiline eliminationHalfLife "Dose Dependent".
- Perhexiline h "35".
- Perhexiline hasPhotoCollection Perhexiline.
- Perhexiline inchi "1".
- Perhexiline inchikey "CYXKNKQEMFBLER-UHFFFAOYAN".
- Perhexiline iupacName "2".
- Perhexiline kegg "D08340".
- Perhexiline metabolism "Saturable Hepatic".
- Perhexiline molecularWeight "277.488".
- Perhexiline n "1".
- Perhexiline pubchem "4746".
- Perhexiline routesOfAdministration "Oral".
- Perhexiline smiles "N3CCCCC3".
- Perhexiline stdinchi "1".
- Perhexiline stdinchikey "CYXKNKQEMFBLER-UHFFFAOYSA-N".
- Perhexiline unii "KU65374X44".
- Perhexiline verifiedrevid "464199017".
- Perhexiline subject Category:Antianginals.
- Perhexiline subject Category:Piperidines.
- Perhexiline type Drug.
- Perhexiline type DrugProduct.
- Perhexiline type FunctionalSubstance.
- Perhexiline comment "Perhexiline (Pexsig) is a prophylactic antianginal agent used primarily in Australia and New Zealand. Perhexiline is thought to act by inhibiting mitochondrial carnitine palmitoyltransferase-1. This shifts myocardial metabolism from fatty acid to glucose utilisation which results in increased ATP production for the same O2 consumption and consequently increases myocardial efficiency.".
- Perhexiline label "Perhexiline".
- Perhexiline sameAs m.08nfc4.
- Perhexiline sameAs Q1232737.
- Perhexiline sameAs Q1232737.
- Perhexiline sameAs DB01074.
- Perhexiline wasDerivedFrom Perhexiline?oldid=573736358.
- Perhexiline depiction Perhexiline_structure.svg.
- Perhexiline isPrimaryTopicOf Perhexiline.