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- Pexacerfont abstract "Pexacerfont (BMS-562,086) is a drug developed by Bristol-Myers Squibb which acts as a CRF-1 antagonist. Corticotropin releasing factor (CRF), also known as Corticotropin releasing hormone, is an endogenous peptide hormone which is released in response to various triggers such as chronic stress. This then triggers the release of corticotropin (ACTH), another hormone which is involved in the physiological response to stress. Chronic release of CRF and ACTH is believed to be directly or indirectly involved in many of the harmful physiological effects of chronic stress, such as excessive glucocorticoid release, diabetes mellitus, osteoporosis, stomach ulcers, anxiety, depression, and development of high blood pressure and consequent cardiovascular problems.Pexacerfont is a recently developed CRF-1 antagonist which is currently in clinical trials for the treatment of anxiety disorders, and has also been proposed to be useful for the treatment of depression and irritable bowel syndrome.A recent multicenter, randomized, double-blind, placebo-controlled trial found that Pexacerfont (100 mg/day) did not separate from placebo on the primary outcome measure (the mean change from baseline to end point in the Hamilton Anxiety Scale score). These results suggest that blockade of CRF-1 receptor may not be a feasible treatment for anxiety disorders in certain human populations.".
- Pexacerfont atcPrefix "none".
- Pexacerfont casNumber "459856-18-9".
- Pexacerfont fdaUniiCode "LF1VBG4ZUK".
- Pexacerfont iupacName "8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine".
- Pexacerfont pubchem "?".
- Pexacerfont thumbnail Pexacerfont.svg?width=300.
- Pexacerfont wikiPageID "15817090".
- Pexacerfont wikiPageRevisionID "545156235".
- Pexacerfont atcPrefix "none".
- Pexacerfont c "18".
- Pexacerfont casNumber "459856".
- Pexacerfont h "24".
- Pexacerfont hasPhotoCollection Pexacerfont.
- Pexacerfont iupacName "8".
- Pexacerfont kegg "D10022".
- Pexacerfont legalStatus "Uncontrolled".
- Pexacerfont molecularWeight "340.4".
- Pexacerfont n "6".
- Pexacerfont o "1".
- Pexacerfont pubchem "?".
- Pexacerfont routesOfAdministration "Oral".
- Pexacerfont unii "LF1VBG4ZUK".
- Pexacerfont verifiedrevid "437186450".
- Pexacerfont subject Category:Anxiolytics.
- Pexacerfont subject Category:Bristol-Myers_Squibb.
- Pexacerfont subject Category:CRF-1_antagonists.
- Pexacerfont subject Category:Corticotropin-releasing_hormone.
- Pexacerfont subject Category:Phenol_ethers.
- Pexacerfont subject Category:Pyridines.
- Pexacerfont type Abstraction100002137.
- Pexacerfont type Base114618253.
- Pexacerfont type Chemical114806838.
- Pexacerfont type Compound114818238.
- Pexacerfont type Element114840755.
- Pexacerfont type Material114580897.
- Pexacerfont type Matter100020827.
- Pexacerfont type Part113809207.
- Pexacerfont type PhenolEthers.
- Pexacerfont type PhysicalEntity100001930.
- Pexacerfont type Pyridine114692510.
- Pexacerfont type Pyridines.
- Pexacerfont type Quintessence114847103.
- Pexacerfont type Relation100031921.
- Pexacerfont type Substance100019613.
- Pexacerfont type Drug.
- Pexacerfont type DrugProduct.
- Pexacerfont type FunctionalSubstance.
- Pexacerfont comment "Pexacerfont (BMS-562,086) is a drug developed by Bristol-Myers Squibb which acts as a CRF-1 antagonist. Corticotropin releasing factor (CRF), also known as Corticotropin releasing hormone, is an endogenous peptide hormone which is released in response to various triggers such as chronic stress. This then triggers the release of corticotropin (ACTH), another hormone which is involved in the physiological response to stress.".
- Pexacerfont label "Pexacerfont".
- Pexacerfont sameAs m.03nwqy0.
- Pexacerfont sameAs Q7179563.
- Pexacerfont sameAs Q7179563.
- Pexacerfont sameAs Pexacerfont.
- Pexacerfont wasDerivedFrom Pexacerfont?oldid=545156235.
- Pexacerfont depiction Pexacerfont.svg.
- Pexacerfont isPrimaryTopicOf Pexacerfont.