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- Phosphoinositide_phospholipase_C abstract "Phosphoinositide phospholipase C (PLC) (EC 3.1.4.11, triphosphoinositide phosphodiesterase, phosphoinositidase C, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, PI-PLC, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase) is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. These enzymes belong to a larger superfamily of Phospholipase C. Other families of phospholipase C enzymes have been identified in bacteria and trypanosomes. Phospholipases C are phosphodiesterases.Phospholipase Cs participate in phosphatidylinositol 4,5-bisphosphate (PIP2) metabolism and lipid signaling pathways in a calcium-dependent manner. At present, the family consists of six sub-families comprising a total of 13 separate isoforms that differ in their mode of activation, expression levels, catalytic regulation, cellular localization, membrane binding avidity and tissue distribution. All are capable of catalyzing the hydrolysis of PIP2 into two important second messenger molecules, which go on to alter cell responses such as proliferation, differentiation, apoptosis, cytoskeleton remodeling, vesicular trafficking, ion channel conductance, endocrine function and neurotransmission.".
- Phosphoinositide_phospholipase_C symbol "PI-PLC-X".
- Phosphoinositide_phospholipase_C symbol "PI-PLC-Y".
- Phosphoinositide_phospholipase_C thumbnail Phospholipase_C-1.png?width=300.
- Phosphoinositide_phospholipase_C wikiPageID "3233543".
- Phosphoinositide_phospholipase_C wikiPageRevisionID "603027089".
- Phosphoinositide_phospholipase_C caption "Phospholipase Cδ-1".
- Phosphoinositide_phospholipase_C caption "activated rac1 bound to its effector phospholipase c beta 2".
- Phosphoinositide_phospholipase_C casNumber "37213".
- Phosphoinositide_phospholipase_C ecNumber "3.1".
- Phosphoinositide_phospholipase_C goCode "4435".
- Phosphoinositide_phospholipase_C hasPhotoCollection Phosphoinositide_phospholipase_C.
- Phosphoinositide_phospholipase_C interpro "IPR000909".
- Phosphoinositide_phospholipase_C interpro "IPR001711".
- Phosphoinositide_phospholipase_C iubmbEcNumber "3".
- Phosphoinositide_phospholipase_C name "PI-PLC-Y".
- Phosphoinositide_phospholipase_C name "Phosphatidylinositol-specific phospholipase C".
- Phosphoinositide_phospholipase_C name "phosphoinositide phospholipase C".
- Phosphoinositide_phospholipase_C opmFamily "126".
- Phosphoinositide_phospholipase_C opmProtein "1".
- Phosphoinositide_phospholipase_C opmProtein "2".
- Phosphoinositide_phospholipase_C pfam "PF00387".
- Phosphoinositide_phospholipase_C pfam "PF00388".
- Phosphoinositide_phospholipase_C pfamClan "CL0384".
- Phosphoinositide_phospholipase_C prosite "PDOC50007".
- Phosphoinositide_phospholipase_C scop "1".
- Phosphoinositide_phospholipase_C smart "PLCXc".
- Phosphoinositide_phospholipase_C smart "PLCYc".
- Phosphoinositide_phospholipase_C symbol "PI-PLC-X".
- Phosphoinositide_phospholipase_C symbol "PI-PLC-Y".
- Phosphoinositide_phospholipase_C width "220".
- Phosphoinositide_phospholipase_C subject Category:Calcium_enzymes.
- Phosphoinositide_phospholipase_C subject Category:Calcium_signaling.
- Phosphoinositide_phospholipase_C subject Category:Cell_biology.
- Phosphoinositide_phospholipase_C subject Category:Cell_signaling.
- Phosphoinositide_phospholipase_C subject Category:EC_3.1.4.
- Phosphoinositide_phospholipase_C subject Category:Enzymes.
- Phosphoinositide_phospholipase_C subject Category:Enzymes_of_known_structure.
- Phosphoinositide_phospholipase_C subject Category:G_protein_coupled_receptors.
- Phosphoinositide_phospholipase_C subject Category:Hydrolases.
- Phosphoinositide_phospholipase_C subject Category:Peripheral_membrane_proteins.
- Phosphoinositide_phospholipase_C subject Category:Protein_families.
- Phosphoinositide_phospholipase_C subject Category:Signal_transduction.
- Phosphoinositide_phospholipase_C type Abstraction100002137.
- Phosphoinositide_phospholipase_C type Activator114723079.
- Phosphoinositide_phospholipase_C type CalciumEnzymes.
- Phosphoinositide_phospholipase_C type Catalyst114723628.
- Phosphoinositide_phospholipase_C type Chemical114806838.
- Phosphoinositide_phospholipase_C type Compound114818238.
- Phosphoinositide_phospholipase_C type Enzyme114732946.
- Phosphoinositide_phospholipase_C type Enzymes.
- Phosphoinositide_phospholipase_C type EnzymesOfKnownStructure.
- Phosphoinositide_phospholipase_C type Macromolecule114944888.
- Phosphoinositide_phospholipase_C type Material114580897.
- Phosphoinositide_phospholipase_C type Matter100020827.
- Phosphoinositide_phospholipase_C type Molecule114682133.
- Phosphoinositide_phospholipase_C type OrganicCompound114727670.
- Phosphoinositide_phospholipase_C type Part113809207.
- Phosphoinositide_phospholipase_C type PeripheralMembraneProteins.
- Phosphoinositide_phospholipase_C type PhysicalEntity100001930.
- Phosphoinositide_phospholipase_C type Protein114728724.
- Phosphoinositide_phospholipase_C type Relation100031921.
- Phosphoinositide_phospholipase_C type Substance100019613.
- Phosphoinositide_phospholipase_C type Thing100002452.
- Phosphoinositide_phospholipase_C type Unit109465459.
- Phosphoinositide_phospholipase_C type Biomolecule.
- Phosphoinositide_phospholipase_C type Protein.
- Phosphoinositide_phospholipase_C type BiologicalObject.
- Phosphoinositide_phospholipase_C comment "Phosphoinositide phospholipase C (PLC) (EC 3.1.4.11, triphosphoinositide phosphodiesterase, phosphoinositidase C, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, PI-PLC, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase) is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes.".
- Phosphoinositide_phospholipase_C label "Phosphoinositide phospholipase C".
- Phosphoinositide_phospholipase_C sameAs m.025snc0.
- Phosphoinositide_phospholipase_C sameAs Q10760862.
- Phosphoinositide_phospholipase_C sameAs Q10760862.
- Phosphoinositide_phospholipase_C sameAs Phosphoinositide_phospholipase_C.
- Phosphoinositide_phospholipase_C wasDerivedFrom Phosphoinositide_phospholipase_C?oldid=603027089.
- Phosphoinositide_phospholipase_C depiction Phospholipase_C-1.png.
- Phosphoinositide_phospholipase_C isPrimaryTopicOf Phosphoinositide_phospholipase_C.
