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- Phosphotyrosine-binding_domain abstract "In molecular biology, Phosphotyrosine-binding domains are protein domains which bind to phosphotyrosine.The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (Pfam PF00017) domain and a region similar to the tumour suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.The phosphotyrosine-binding domain of insulin receptor substrate-1 is not related to the phosphotyrosine-binding domain of tensin.Insulin receptor substrate-1 proteins contain both a pleckstrin homology domain and a phosphotyrosine binding (PTB) domain. The PTB domains facilitate interaction with the activated tyrosine-phosphorylated insulin receptor. The PTB domain is situated towards the N terminus. Two arginines in this domain are responsible for hydrogen bonding phosphotyrosine residues on an Ac-LYASSNPApY-NH2 peptide in the juxtamembrane region of the insulin receptor. Further interactions via "bridged" water molecules are coordinated by residues an Asn and a Ser residue. The PTB domain has a compact, 7-stranded beta-sandwich structure, capped by a C-terminal helix. The substrate peptide fits into an L-shaped surface cleft formed from the C-terminal helix and strands 5 and 6.".
- Phosphotyrosine-binding_domain symbol "IRS".
- Phosphotyrosine-binding_domain symbol "PTB".
- Phosphotyrosine-binding_domain thumbnail PDB_1wvh_EBI.jpg?width=300.
- Phosphotyrosine-binding_domain wikiPageID "24010095".
- Phosphotyrosine-binding_domain wikiPageRevisionID "605656765".
- Phosphotyrosine-binding_domain caption "Structure of the PTB domain of tensin1.".
- Phosphotyrosine-binding_domain caption "irs-1 ptb domain complexed with a il-4 receptor phosphopeptide, nmr, minimized average structure".
- Phosphotyrosine-binding_domain cdd "cd00934".
- Phosphotyrosine-binding_domain cdd "cd01204".
- Phosphotyrosine-binding_domain hasPhotoCollection Phosphotyrosine-binding_domain.
- Phosphotyrosine-binding_domain interpro "IPR002404".
- Phosphotyrosine-binding_domain interpro "IPR013625".
- Phosphotyrosine-binding_domain name "PTB domain".
- Phosphotyrosine-binding_domain name "Phosphotyrosine-binding domain".
- Phosphotyrosine-binding_domain pdb "A:1607-1738".
- Phosphotyrosine-binding_domain pfam "PF02174".
- Phosphotyrosine-binding_domain pfam "PF08416".
- Phosphotyrosine-binding_domain scop "1".
- Phosphotyrosine-binding_domain smart "PTBI".
- Phosphotyrosine-binding_domain symbol "IRS".
- Phosphotyrosine-binding_domain symbol "PTB".
- Phosphotyrosine-binding_domain subject Category:Membrane_proteins.
- Phosphotyrosine-binding_domain subject Category:Protein_domains.
- Phosphotyrosine-binding_domain subject Category:Protein_families.
- Phosphotyrosine-binding_domain type Abstraction100002137.
- Phosphotyrosine-binding_domain type Attribute100024264.
- Phosphotyrosine-binding_domain type Chemical114806838.
- Phosphotyrosine-binding_domain type Compound114818238.
- Phosphotyrosine-binding_domain type Environment113934596.
- Phosphotyrosine-binding_domain type Macromolecule114944888.
- Phosphotyrosine-binding_domain type Material114580897.
- Phosphotyrosine-binding_domain type Matter100020827.
- Phosphotyrosine-binding_domain type MembraneProteins.
- Phosphotyrosine-binding_domain type Molecule114682133.
- Phosphotyrosine-binding_domain type OrganicCompound114727670.
- Phosphotyrosine-binding_domain type Part113809207.
- Phosphotyrosine-binding_domain type PhysicalEntity100001930.
- Phosphotyrosine-binding_domain type Protein114728724.
- Phosphotyrosine-binding_domain type ProteinDomains.
- Phosphotyrosine-binding_domain type Relation100031921.
- Phosphotyrosine-binding_domain type Situation113927383.
- Phosphotyrosine-binding_domain type Sphere114514039.
- Phosphotyrosine-binding_domain type State100024720.
- Phosphotyrosine-binding_domain type Substance100019613.
- Phosphotyrosine-binding_domain type Thing100002452.
- Phosphotyrosine-binding_domain type Unit109465459.
- Phosphotyrosine-binding_domain type Biomolecule.
- Phosphotyrosine-binding_domain type Protein.
- Phosphotyrosine-binding_domain type BiologicalObject.
- Phosphotyrosine-binding_domain comment "In molecular biology, Phosphotyrosine-binding domains are protein domains which bind to phosphotyrosine.The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix).".
- Phosphotyrosine-binding_domain label "Phosphotyrosine-binding domain".
- Phosphotyrosine-binding_domain sameAs m.07kb22p.
- Phosphotyrosine-binding_domain sameAs Q7187588.
- Phosphotyrosine-binding_domain sameAs Q7187588.
- Phosphotyrosine-binding_domain sameAs Phosphotyrosine-binding_domain.
- Phosphotyrosine-binding_domain wasDerivedFrom Phosphotyrosine-binding_domain?oldid=605656765.
- Phosphotyrosine-binding_domain depiction PDB_1wvh_EBI.jpg.
- Phosphotyrosine-binding_domain isPrimaryTopicOf Phosphotyrosine-binding_domain.