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- Physiologically_based_pharmacokinetic_modelling abstract "Physiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique for predicting the absorption, distribution, metabolism and excretion (ADME) of synthetic or natural chemical substances in humans and other animal species. PBPK modeling is used in pharmaceutical research and drug development, and in health risk assessment for cosmetics or general chemicals.PBPK models strive to be mechanistic by mathematically transcribing anatomical, physiological, physical, and chemical descriptions of the phenomena involved in the complex ADME processes. A large degree of residual simplification and empiricism is still present in those models, but they have an extended domain of applicability compared to that of classical, empirical function based, pharmacokinetic models. PBPK models may have purely predictive uses, but other uses, such as statistical inference, have been made possible by the development of Bayesian statistical tools able to deal with complex models. That is true for both toxicity risk assessment and therapeutic drug development.PBPK models try to rely a priori on the anatomical and physiological structure of the body, and to a certain extent, on biochemistry. They are usually multi-compartment models, with compartments corresponding to predefined organs or tissues, with interconnections corresponding to blood or lymph flows (more rarely to diffusions). A system of differential equations for concentration or quantity of substance on each compartment can be written, and its parameters represent blood flows, pulmonary ventilation rate, organ volumes etc., for which information is available in scientific publications. Indeed the description they make of the body is simplified and a balance needs to be struck between complexity and simplicity. Besides the advantage of allowing the recruitment of a priori information about parameter values, these models also facilitate inter-species transpositions or extrapolation from one mode of administration to another (e.g., inhalation to oral). An example of a 7-compartment PBTK model, suitable to describe the fate of many solvents in the mammalian body, is given in the Figure on the right.".
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- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink bmsr.usc.edu.
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- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.admewb.com.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.berkeleymadonna.com.
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- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.ecolego.facilia.se.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.ecotoxmodels.org.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.entelos.com.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink mcsim.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.icondevsolutions.com.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.mathworks.com.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.maxsim2.com.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.modelkinetix.com.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.octave.org.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.pbpk.org.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.pk-sim.com.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.pkquest.com.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.r-project.org.
- Physiologically_based_pharmacokinetic_modelling wikiPageExternalLink www.simcyp.com.
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- Physiologically_based_pharmacokinetic_modelling wikiPageID "1566437".
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- Physiologically_based_pharmacokinetic_modelling hasPhotoCollection Physiologically_based_pharmacokinetic_modelling.
- Physiologically_based_pharmacokinetic_modelling subject Category:Pharmacokinetics.
- Physiologically_based_pharmacokinetic_modelling subject Category:Pharmacology.
- Physiologically_based_pharmacokinetic_modelling subject Category:Pharmacy.
- Physiologically_based_pharmacokinetic_modelling subject Category:Toxicology.
- Physiologically_based_pharmacokinetic_modelling subject Category:Toxicokinetics.
- Physiologically_based_pharmacokinetic_modelling comment "Physiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique for predicting the absorption, distribution, metabolism and excretion (ADME) of synthetic or natural chemical substances in humans and other animal species.".
- Physiologically_based_pharmacokinetic_modelling label "Fysiologisch gebaseerd farmacokinetisch model".
- Physiologically_based_pharmacokinetic_modelling label "Modelado PBPK".
- Physiologically_based_pharmacokinetic_modelling label "Modèles PBPK".
- Physiologically_based_pharmacokinetic_modelling label "Physiologically based pharmacokinetic modelling".
- Physiologically_based_pharmacokinetic_modelling sameAs Modelado_PBPK.
- Physiologically_based_pharmacokinetic_modelling sameAs Modèles_PBPK.
- Physiologically_based_pharmacokinetic_modelling sameAs Fysiologisch_gebaseerd_farmacokinetisch_model.
- Physiologically_based_pharmacokinetic_modelling sameAs m.05byqd.
- Physiologically_based_pharmacokinetic_modelling sameAs Q2562769.
- Physiologically_based_pharmacokinetic_modelling sameAs Q2562769.
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