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- Polymyxin_B abstract "Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa. Polymyxin B is composed of a number of related compounds (see "Mixture Composition"). It has a bactericidal action against almost all Gram-negative bacilli except the Proteus and Neisseria genera. Polymyxins bind to the cell membrane and alter its structure, making it more permeable. The resulting water uptake leads to cell death. Polymyxins are cationic, basic proteins that act like detergents (surfactants). Side effects include neurotoxicity and acute renal tubular necrosis. Polymyxins are used in the topical first-aid preparation Neosporin.Family of polypeptides with attached fatty acid; cationic detergent at physiological pH, both hydrophilic and hydrophobic propertiesBactericidal for gram-negative; little to no effect on gram-positive, since cell wall is too thick to permit access to membrane".
- Polymyxin_B atcPrefix "A07".
- Polymyxin_B atcSuffix "AA05".
- Polymyxin_B casNumber "1405-20-5".
- Polymyxin_B drugbank "DB00781".
- Polymyxin_B iupacName "N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide".
- Polymyxin_B pubchem "5702105".
- Polymyxin_B thumbnail Polymyxin_B1.svg?width=300.
- Polymyxin_B wikiPageID "5155469".
- Polymyxin_B wikiPageRevisionID "604040639".
- Polymyxin_B atcPrefix "A07".
- Polymyxin_B atcSuffix "AA05".
- Polymyxin_B c "56".
- Polymyxin_B casNumber "1405".
- Polymyxin_B chembl "1201283".
- Polymyxin_B drugbank "DB00781".
- Polymyxin_B h "100".
- Polymyxin_B hasPhotoCollection Polymyxin_B.
- Polymyxin_B image "polymyxin B2.svg".
- Polymyxin_B iupacName "N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris-15-benzyl-3--12--2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide".
- Polymyxin_B legalStatus "OTC".
- Polymyxin_B molecularWeight "1301.56".
- Polymyxin_B n "16".
- Polymyxin_B niaidChemdb "7797".
- Polymyxin_B o "17".
- Polymyxin_B pregnancyCategory "C".
- Polymyxin_B pubchem "5702105".
- Polymyxin_B routesOfAdministration "Topical, Intramuscular, Intravenous, Intrathecal, or Ophthalmic".
- Polymyxin_B s "1".
- Polymyxin_B verifiedfields "changed".
- Polymyxin_B verifiedrevid "414279035".
- Polymyxin_B watchedfields "changed".
- Polymyxin_B subject Category:Cyclic_peptides.
- Polymyxin_B subject Category:Otologicals.
- Polymyxin_B subject Category:Polymyxin_antibiotics.
- Polymyxin_B type Agent114778436.
- Polymyxin_B type Antibacterial102716205.
- Polymyxin_B type Antibiotic102716866.
- Polymyxin_B type CausalAgent100007347.
- Polymyxin_B type Drug103247620.
- Polymyxin_B type Matter100020827.
- Polymyxin_B type Medicine103740161.
- Polymyxin_B type PhysicalEntity100001930.
- Polymyxin_B type PolymyxinAntibiotics.
- Polymyxin_B type Substance100020090.
- Polymyxin_B type Drug.
- Polymyxin_B type DrugProduct.
- Polymyxin_B type FunctionalSubstance.
- Polymyxin_B comment "Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa. Polymyxin B is composed of a number of related compounds (see "Mixture Composition"). It has a bactericidal action against almost all Gram-negative bacilli except the Proteus and Neisseria genera. Polymyxins bind to the cell membrane and alter its structure, making it more permeable. The resulting water uptake leads to cell death.".
- Polymyxin_B label "Polimixina B".
- Polymyxin_B label "Polimyksyna B".
- Polymyxin_B label "Polymyxin B".
- Polymyxin_B label "多粘菌素B".
- Polymyxin_B sameAs Polimixina_B.
- Polymyxin_B sameAs Polimyksyna_B.
- Polymyxin_B sameAs m.0d5br5.
- Polymyxin_B sameAs Q1088175.
- Polymyxin_B sameAs Q1088175.
- Polymyxin_B sameAs polymyxin_b.
- Polymyxin_B sameAs DB00781.
- Polymyxin_B sameAs Polymyxin_B.
- Polymyxin_B wasDerivedFrom Polymyxin_B?oldid=604040639.
- Polymyxin_B depiction Polymyxin_B1.svg.
- Polymyxin_B isPrimaryTopicOf Polymyxin_B.