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- Primidone abstract "Primidone is an anticonvulsant of the pyrimidinedione class, the active metabolites of which, phenobarbital (minor) and phenylethylmalonamide (PEMA) (major), are also anticonvulsants. It is used mainly to treat complex partial, simple partial, generalized tonic-clonic seizures, myoclonic, and akinetic seizures. Since the 1980s it has been a valuable alternative to propranolol in the treatment of essential tremor. Unlike other anticonvulsants such as carbamazepine and valproic acid, primidone is rarely used in the treatment of bipolar disorder or any other psychiatric problem, although this presents a risk for the worsening of some disorders. It is also occasionally used in treatment of neuropathic pain, trigeminal neuralgia, and migraine. Primidone has been occasionally used to treat long QT syndrome, cerebral palsy, and athetosis.Primidone was once a mainstay anticonvulsant in the treatment of partial and generalized seizures and was the treatment of choice for secondarily generalized seizures originating in the temporal lobes, especially when combined with phenytoin, but by the early 1980s, carbamazepine had surpassed it in popularity due to the latter's lower incidence of sedation. As time passed and more and more anticonvulsants came on the market, primidone was pushed further and further away from its former place of prominence and major Western pharmaceutical corporations became less and less interested in manufacturing and selling it. It has largely fallen into disuse in the developed world as more and more anticonvulsants entered the market and has been withdrawn from markets all over the world.Unlike many other anticonvulsants, primidone works via interactions with voltage-gated sodium channels which inhibit high-frequency repetitive firing of action potentials. It is much less toxic in overdose than phenobarbital. Along with carbamazepine, phenobarbital, and phenytoin, primidone is an inducer of metabolic enzymes in the liver, which means that it accelerates the metabolism of many other pharmaceuticals. Like other anticonvulsants that entered the market before 1989, primidone has been associated with hyperhomocysteinemia, folate deficiency and its various symptoms (birth defects, depression, and megaloblastic anemia), reduced calcium absorption, and various bone diseases. It also shares with most other anticonvulsants the tendency to cause sedation.".
- Primidone atcPrefix "N03".
- Primidone atcSuffix "AA03".
- Primidone casNumber "125-33-7".
- Primidone drugbank "DB00794".
- Primidone fdaUniiCode "13AFD7670Q".
- Primidone iupacName "5-ethyl-5-phenyl-hexahydropyrimidine-4,6-dione".
- Primidone pubchem "4909".
- Primidone thumbnail Primidone_structure.svg?width=300.
- Primidone wikiPageExternalLink index.cfm?objectid=070AA2DE-BEEC-884F-558DED2D4C3BEAD6.
- Primidone wikiPageExternalLink icn.html.
- Primidone wikiPageExternalLink www.valeant.com.
- Primidone wikiPageID "2157713".
- Primidone wikiPageRevisionID "605740006".
- Primidone atcPrefix "N03".
- Primidone atcSuffix "AA03".
- Primidone bioavailability "~100%".
- Primidone c "12".
- Primidone casNumber "125".
- Primidone chembl "856".
- Primidone chemspiderid "4740".
- Primidone drugbank "DB00794".
- Primidone eliminationHalfLife "-259200.0".
- Primidone eliminationHalfLife "-432000.0".
- Primidone eliminationHalfLife "-64800.0".
- Primidone eliminationHalfLife "57600.0".
- Primidone eliminationHalfLife "Phenobarbital&PEMA 1-4weeks".
- Primidone eliminationHalfLife "Time to reach steady state:".
- Primidone excretion Kidney.
- Primidone h "14".
- Primidone hasPhotoCollection Primidone.
- Primidone image "Primidone ball-and-stick.png".
- Primidone inchi "1".
- Primidone inchikey "DQMZLTXERSFNPB-UHFFFAOYAX".
- Primidone iupacName "5".
- Primidone kegg "D00474".
- Primidone legalUk "POM".
- Primidone legalUs "Rx-only".
- Primidone metabolism Liver.
- Primidone molecularWeight "218.252".
- Primidone n "2".
- Primidone o "2".
- Primidone pregnancyUs "D".
- Primidone proteinBound "25.0".
- Primidone pubchem "4909".
- Primidone routesOfAdministration "oral".
- Primidone smiles "O=C1NCNCC1CC".
- Primidone stdinchi "1".
- Primidone stdinchikey "DQMZLTXERSFNPB-UHFFFAOYSA-N".
- Primidone unii "13".
- Primidone verifiedrevid "462079478".
- Primidone width "127".
- Primidone width "150".
- Primidone subject Category:Barbiturates.
- Primidone subject Category:Pyrimidinediones.
- Primidone subject Category:Treatment_of_bipolar_disorder.
- Primidone type Drug.
- Primidone type DrugProduct.
- Primidone type FunctionalSubstance.
- Primidone comment "Primidone is an anticonvulsant of the pyrimidinedione class, the active metabolites of which, phenobarbital (minor) and phenylethylmalonamide (PEMA) (major), are also anticonvulsants. It is used mainly to treat complex partial, simple partial, generalized tonic-clonic seizures, myoclonic, and akinetic seizures. Since the 1980s it has been a valuable alternative to propranolol in the treatment of essential tremor.".
- Primidone label "Primidon".
- Primidone label "Primidona".
- Primidone label "Primidone".
- Primidone label "Primidone".
- Primidone label "Primidone".
- Primidone label "Примидон".
- Primidone sameAs Primidon.
- Primidone sameAs Primidone.
- Primidone sameAs Primidone.
- Primidone sameAs Primidona.
- Primidone sameAs m.06r2rh.
- Primidone sameAs Q420383.
- Primidone sameAs Q420383.
- Primidone sameAs Primidone.
- Primidone sameAs DB00794.
- Primidone sameAs 4909.
- Primidone wasDerivedFrom Primidone?oldid=605740006.
- Primidone depiction Primidone_structure.svg.
- Primidone homepage www.valeant.com.
- Primidone isPrimaryTopicOf Primidone.