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- Pristinamycin abstract "Pristinamycin (INN), also spelled pristinamycine, is an antibiotic used primarily in the treatment of staphylococcal infections, and to a lesser extent streptococcal infections. It is a streptogramin group antibiotic, similar to virginiamycin, derived from the bacterium Streptomyces pristinaespiralis. It is marketed in Europe by Sanofi-Aventis under the trade name Synercid and Pyostacine.Pristinamycin is a mixture of two components that have a synergistic antibacterial action. Pristinamycin IA is a macrolide, and results in pristinamycin's having a similar spectrum of action to erythromycin. Pristinamycin IIA (streptogramin A) is a depsipeptide. PI and PII are coproduced by S. pristinaespiralis in a ratio of 30:70. Each compound binds to the bacterial 50 S ribosomal subunit and inhibits the elongation process of the protein synthesis, thereby exhibiting only a moderate bacteriostatic activity. However, the combination of both substances acts synergistically and leads to a potent bactericidal activity that can reach up to 100 times that of the separate components.The pristinamycin biosynthetic gene cluster is the largest antibiotic supercluster known so far, with a size of ~210 kb, wherein the PI and PII biosynthetic genes are not clustered individually but are scattered across the complete sequence region. Furthermore, this biosynthetic gene region is interrupted by a cryptic type II PKS gene cluster.".
- Pristinamycin atcPrefix "J01".
- Pristinamycin atcSuffix "FG01".
- Pristinamycin casNumber "270076-60-3".
- Pristinamycin pubchem "11979535".
- Pristinamycin thumbnail Pristinamycin_IA.png?width=300.
- Pristinamycin wikiPageID "3675099".
- Pristinamycin wikiPageRevisionID "586718129".
- Pristinamycin atcPrefix "J01".
- Pristinamycin atcSuffix "FG01".
- Pristinamycin casNumber "270076".
- Pristinamycin chembl "1256399".
- Pristinamycin chemspiderid "10152812".
- Pristinamycin class Antibiotics.
- Pristinamycin component "Pristinamycin IA".
- Pristinamycin component "Pristinamycin IIA".
- Pristinamycin hasPhotoCollection Pristinamycin.
- Pristinamycin image "Streptogramin A.svg".
- Pristinamycin inchi "1".
- Pristinamycin inchikey "MVTQIFVKRXBCHS-FHWPYUEJBW".
- Pristinamycin medlineplus "a603007".
- Pristinamycin pubchem "11979535".
- Pristinamycin smiles "CCC1CN2CCCC2CNC.CC1/C=C\CNC/C=C\C\C".
- Pristinamycin stdinchi "1".
- Pristinamycin stdinchikey "MVTQIFVKRXBCHS-FHWPYUEJSA-N".
- Pristinamycin type "combo".
- Pristinamycin verifiedfields "changed".
- Pristinamycin verifiedrevid "464214518".
- Pristinamycin subject Category:Antibiotics.
- Pristinamycin subject Category:Combination_antibiotics.
- Pristinamycin subject Category:Cyclic_peptides.
- Pristinamycin subject Category:Depsipeptides.
- Pristinamycin type Agent114778436.
- Pristinamycin type Antibacterial102716205.
- Pristinamycin type Antibiotic102716866.
- Pristinamycin type Antibiotics.
- Pristinamycin type CausalAgent100007347.
- Pristinamycin type CombinationAntibiotics.
- Pristinamycin type Drug103247620.
- Pristinamycin type Matter100020827.
- Pristinamycin type Medicine103740161.
- Pristinamycin type PhysicalEntity100001930.
- Pristinamycin type Substance100020090.
- Pristinamycin type Drug.
- Pristinamycin type DrugProduct.
- Pristinamycin type FunctionalSubstance.
- Pristinamycin comment "Pristinamycin (INN), also spelled pristinamycine, is an antibiotic used primarily in the treatment of staphylococcal infections, and to a lesser extent streptococcal infections. It is a streptogramin group antibiotic, similar to virginiamycin, derived from the bacterium Streptomyces pristinaespiralis. It is marketed in Europe by Sanofi-Aventis under the trade name Synercid and Pyostacine.Pristinamycin is a mixture of two components that have a synergistic antibacterial action.".
- Pristinamycin label "Pristinamicina".
- Pristinamycin label "Pristinamycin".
- Pristinamycin label "Pristinamycin".
- Pristinamycin label "Pristinamycine".
- Pristinamycin label "Pristynamycyna".
- Pristinamycin label "بريستينامايسين".
- Pristinamycin sameAs Pristinamycin.
- Pristinamycin sameAs Pristinamycine.
- Pristinamycin sameAs Pristinamicina.
- Pristinamycin sameAs Pristynamycyna.
- Pristinamycin sameAs m.09tszg.
- Pristinamycin sameAs Q423412.
- Pristinamycin sameAs Q423412.
- Pristinamycin sameAs Pristinamycin.
- Pristinamycin wasDerivedFrom Pristinamycin?oldid=586718129.
- Pristinamycin depiction Pristinamycin_IA.png.
- Pristinamycin isPrimaryTopicOf Pristinamycin.