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- Proglumide abstract "Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs. This can make it a useful adjuvant treatment to use alongside opioid drugs in the treatment of chronic pain conditions such as cancer, where opioid analgesics may be required for long periods and development of tolerance reduces clinical efficacy of these drugs.Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic effects.Proglumide also works as a placebo effect amplifier for pain conditions. When injected visibly to a subject, its analgesic effect is bigger than a similarly administered placebo. When injected secretly, it does not have any effect, whereas standard pain drugs have an effect, even if they are administered without the subject's awareness. The supposed mechanism is an enhancement of the neural pathways of expectation.".
- Proglumide atcPrefix "A02".
- Proglumide atcSuffix "BX06".
- Proglumide casNumber "6620-60-6".
- Proglumide chEBI "32058".
- Proglumide fdaUniiCode "EPL8W5565D".
- Proglumide iupacName "(RS)-N2-benzoyl-N,N-dipropyl-α-glutamine".
- Proglumide pubchem "4922".
- Proglumide thumbnail Proglumide_structure.svg?width=300.
- Proglumide wikiPageID "14409298".
- Proglumide wikiPageRevisionID "594077074".
- Proglumide atcPrefix "A02".
- Proglumide atcSuffix "BX06".
- Proglumide c "18".
- Proglumide casNumber "6620".
- Proglumide chebi "32058".
- Proglumide chembl "316561".
- Proglumide drugName "Proglumide".
- Proglumide eliminationHalfLife "86400.0".
- Proglumide h "26".
- Proglumide hasPhotoCollection Proglumide.
- Proglumide imagename "Chemical structure of proglumide".
- Proglumide iupacName "-N2-benzoyl-N,N-dipropyl-α-glutamine".
- Proglumide iupharLigand "893".
- Proglumide legalStatus "Rx-only".
- Proglumide molecularWeight "334.41".
- Proglumide n "2".
- Proglumide o "4".
- Proglumide pubchem "4922".
- Proglumide routesOfAdministration "Oral".
- Proglumide smiles "O=CC1=CC=CC=C1".
- Proglumide synonyms "(4-benzamido-5--5-oxopentanoic acid)".
- Proglumide unii "EPL8W5565D".
- Proglumide verifiedfields "changed".
- Proglumide verifiedrevid "405764009".
- Proglumide watchedfields "changed".
- Proglumide width "200".
- Proglumide subject Category:Amides.
- Proglumide subject Category:Benzamides.
- Proglumide subject Category:Cholecystokinin_antagonists.
- Proglumide type Adversary109773245.
- Proglumide type CausalAgent100007347.
- Proglumide type CholecystokininAntagonists.
- Proglumide type LivingThing100004258.
- Proglumide type Object100002684.
- Proglumide type Organism100004475.
- Proglumide type Person100007846.
- Proglumide type PhysicalEntity100001930.
- Proglumide type Whole100003553.
- Proglumide type YagoLegalActor.
- Proglumide type YagoLegalActorGeo.
- Proglumide type Drug.
- Proglumide type DrugProduct.
- Proglumide type FunctionalSubstance.
- Proglumide comment "Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs.".
- Proglumide label "Proglumide".
- Proglumide label "بروغلوميد".
- Proglumide sameAs m.03d2myh.
- Proglumide sameAs Q7248362.
- Proglumide sameAs Q7248362.
- Proglumide sameAs Proglumide.
- Proglumide wasDerivedFrom Proglumide?oldid=594077074.
- Proglumide depiction Proglumide_structure.svg.
- Proglumide isPrimaryTopicOf Proglumide.
- Proglumide name "Proglumide".