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- Proprotein_convertase_2 abstract "Proprotein convertase 2 (PC2) also known as prohormone convertase 2 or neuroendocrine convertase 2 (NEC2) is a serine protease and proprotein convertase PC2, like proprotein convertase 1 (PC1), is an enzyme responsible for the first step in the maturation of many neuroendocrine peptides from their precursors, such as the conversion of proinsulin to insulin intermediates. To generate the bioactive form of insulin (and many other peptides), a second step involving the removal of C-terminal basic residues is required; this step is mediated by carboxypeptidases E and/or D. PC2 plays only a minor role in the first step of insulin biosynthesis, but a greater role in the first step of glucagon biosynthesis compared to PC1. PC2 binds to the neuroendocrine protein named 7B2, and if this protein is not present, proPC2 cannot become enzymatically active. 7B2 accomplishes this by preventing the aggregation of proPC2 to inactivatable forms. The C-terminal domain of 7B2 also inhibits PC2 activity until it is cleaved into smaller inactive forms. Thus, 7B2 is both an activator and an inhibitor of PC2.In humans, proprotein convertase 2 is encoded by the PCSK2 gene. It is related to the bacterial enzyme subtilisin, and altogether there are 9 different subtilisin-like genes in mammals: furin, PACE4, PC4, PC5/6, PC7/8, PCSK9, and SKI1/S1P.".
- Proprotein_convertase_2 entrezgene "5126".
- Proprotein_convertase_2 wikiPageID "5597541".
- Proprotein_convertase_2 wikiPageRevisionID "592860632".
- Proprotein_convertase_2 casNumber "130960".
- Proprotein_convertase_2 ecNumber "3.4".
- Proprotein_convertase_2 goCode "4286".
- Proprotein_convertase_2 hasPhotoCollection Proprotein_convertase_2.
- Proprotein_convertase_2 iubmbEcNumber "3".
- Proprotein_convertase_2 name "proprotein convertase 2".
- Proprotein_convertase_2 subject Category:EC_3.4.21.
- Proprotein_convertase_2 type Biomolecule.
- Proprotein_convertase_2 type Protein.
- Proprotein_convertase_2 type BiologicalObject.
- Proprotein_convertase_2 comment "Proprotein convertase 2 (PC2) also known as prohormone convertase 2 or neuroendocrine convertase 2 (NEC2) is a serine protease and proprotein convertase PC2, like proprotein convertase 1 (PC1), is an enzyme responsible for the first step in the maturation of many neuroendocrine peptides from their precursors, such as the conversion of proinsulin to insulin intermediates.".
- Proprotein_convertase_2 label "Proprotein convertase 2".
- Proprotein_convertase_2 sameAs m.02p9htq.
- Proprotein_convertase_2 sameAs Q7250440.
- Proprotein_convertase_2 sameAs Q7250440.
- Proprotein_convertase_2 sameAs 3847.
- Proprotein_convertase_2 wasDerivedFrom Proprotein_convertase_2?oldid=592860632.
- Proprotein_convertase_2 isPrimaryTopicOf Proprotein_convertase_2.