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- Protein_C abstract "Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death, and maintaining the permeability of blood vessel walls in humans and other animals. Activated protein C (APC) performs these operations primarily by proteolytically inactivating proteins Factor Va and Factor VIIIa. APC is classified as a serine protease as it contains a residue of serine in its active site. In humans, protein C is encoded by the PROC gene, which is found on chromosome 2.The zymogenic form of protein C is a vitamin K-dependent glycoprotein that circulates in blood plasma. Its structure is that of a two-chain polypeptide consisting of a light chain and a heavy chain connected by a disulfide bond. The protein C zymogen is activated when it binds to thrombin, another protein heavily involved in coagulation, and protein C's activation is greatly promoted by the presence of thrombomodulin and endothelial protein C receptors (EPCRs). Because of EPCR's role, activated protein C is found primarily near endothelial cells (i.e., those that make up the walls of blood vessels), and it is these cells and leukocytes (white blood cells) that APC affects. Because of the crucial role that protein C plays as an anticoagulant, those with deficiencies in protein C, or some kind of resistance to APC, suffer from a significantly increased risk of forming dangerous blood clots (thrombosis).Research into the clinical use of activated protein C also known as drotrecogin alfa-activated (branded Xigris) has been surrounded by controversy. The manufacturer Eli Lilly and Company ran an aggressive marketing campaign to promote its use in people with severe sepsis and septic shock including the sponsoring of the 2004Surviving Sepsis Campaign Guidelines. A 2011 Cochrane review however found that its use cannot be recommended as it does not improve survival (and increases bleeding risk).".
- Protein_C entrezgene "5624".
- Protein_C thumbnail Protein_C_1D_schematic.png?width=300.
- Protein_C wikiPageExternalLink merops.cgi?id=S01.218.
- Protein_C wikiPageExternalLink summary.
- Protein_C wikiPageExternalLink ucm152843.htm.
- Protein_C wikiPageExternalLink aPC.htm.
- Protein_C wikiPageExternalLink Protein_C.htm.
- Protein_C wikiPageExternalLink 612283.
- Protein_C wikiPageExternalLink entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5624.
- Protein_C wikiPageExternalLink index.html.
- Protein_C wikiPageExternalLink research.html.
- Protein_C wikiPageID "1364354".
- Protein_C wikiPageRevisionID "599196898".
- Protein_C colwidth "30".
- Protein_C hasPhotoCollection Protein_C.
- Protein_C subject Category:Angiology.
- Protein_C subject Category:Coagulation_system.
- Protein_C subject Category:EC_3.4.21.
- Protein_C subject Category:Hematology.
- Protein_C subject Category:Peripheral_membrane_proteins.
- Protein_C type Abstraction100002137.
- Protein_C type Chemical114806838.
- Protein_C type Compound114818238.
- Protein_C type Macromolecule114944888.
- Protein_C type Material114580897.
- Protein_C type Matter100020827.
- Protein_C type Molecule114682133.
- Protein_C type OrganicCompound114727670.
- Protein_C type Part113809207.
- Protein_C type PeripheralMembraneProteins.
- Protein_C type PhysicalEntity100001930.
- Protein_C type Protein114728724.
- Protein_C type Relation100031921.
- Protein_C type Substance100019613.
- Protein_C type Thing100002452.
- Protein_C type Unit109465459.
- Protein_C type Biomolecule.
- Protein_C type Protein.
- Protein_C type BiologicalObject.
- Protein_C comment "Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death, and maintaining the permeability of blood vessel walls in humans and other animals. Activated protein C (APC) performs these operations primarily by proteolytically inactivating proteins Factor Va and Factor VIIIa.".
- Protein_C label "Białko C".
- Protein_C label "Protein C".
- Protein_C label "Protein C".
- Protein_C label "Proteina C".
- Protein_C label "Proteína C".
- Protein_C label "Proteína C".
- Protein_C label "Proteïne C".
- Protein_C label "Protéine C".
- Protein_C label "Протеин C".
- Protein_C label "بروتين سي".
- Protein_C sameAs Protein_C.
- Protein_C sameAs Proteína_C.
- Protein_C sameAs Protéine_C.
- Protein_C sameAs Protein_C.
- Protein_C sameAs Proteina_C.
- Protein_C sameAs Proteïne_C.
- Protein_C sameAs Białko_C.
- Protein_C sameAs Proteína_C.
- Protein_C sameAs PROC.
- Protein_C sameAs m.04wy9b.
- Protein_C sameAs Q412810.
- Protein_C sameAs Q412810.
- Protein_C sameAs Protein_C.
- Protein_C wasDerivedFrom Protein_C?oldid=599196898.
- Protein_C depiction Protein_C_1D_schematic.png.
- Protein_C isPrimaryTopicOf Protein_C.