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- Protein_kinase_domain abstract "The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases. Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation. This functions as an on/off switch for many cellular processes, including metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. They also function in embryonic development, physiological responses, and in the nervous and immune system. Abnormal phosphorylation causes many human diseases, including cancer, and drugs that affect phosphorylation can treat those diseases.Protein kinases possess a catalytic subunit which transfers the gamma phosphate from nucleoside triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. These enzymes fall into two broad classes, characterised with respect to substrate specificity: serine/threonine specific and tyrosine specific.".
- Protein_kinase_domain symbol "Pkinase".
- Protein_kinase_domain thumbnail PDB_1apm_EBI.jpg?width=300.
- Protein_kinase_domain wikiPageID "14654371".
- Protein_kinase_domain wikiPageRevisionID "597351430".
- Protein_kinase_domain caption "Structure of the catalytic subunit of cAMP-dependent protein kinase.".
- Protein_kinase_domain cdd "cd00180".
- Protein_kinase_domain hasPhotoCollection Protein_kinase_domain.
- Protein_kinase_domain interpro "IPR000719".
- Protein_kinase_domain name "Protein kinase domain".
- Protein_kinase_domain opmFamily "417".
- Protein_kinase_domain opmProtein "2".
- Protein_kinase_domain pfam "PF00069".
- Protein_kinase_domain prosite "PDOC00629".
- Protein_kinase_domain scop "1".
- Protein_kinase_domain smart "TyrKc".
- Protein_kinase_domain symbol "Pkinase".
- Protein_kinase_domain subject Category:Peripheral_membrane_proteins.
- Protein_kinase_domain subject Category:Protein_domains.
- Protein_kinase_domain type Abstraction100002137.
- Protein_kinase_domain type Attribute100024264.
- Protein_kinase_domain type Chemical114806838.
- Protein_kinase_domain type Compound114818238.
- Protein_kinase_domain type Environment113934596.
- Protein_kinase_domain type Macromolecule114944888.
- Protein_kinase_domain type Material114580897.
- Protein_kinase_domain type Matter100020827.
- Protein_kinase_domain type Molecule114682133.
- Protein_kinase_domain type OrganicCompound114727670.
- Protein_kinase_domain type Part113809207.
- Protein_kinase_domain type PeripheralMembraneProteins.
- Protein_kinase_domain type PhysicalEntity100001930.
- Protein_kinase_domain type Protein114728724.
- Protein_kinase_domain type ProteinDomains.
- Protein_kinase_domain type Relation100031921.
- Protein_kinase_domain type Situation113927383.
- Protein_kinase_domain type Sphere114514039.
- Protein_kinase_domain type State100024720.
- Protein_kinase_domain type Substance100019613.
- Protein_kinase_domain type Thing100002452.
- Protein_kinase_domain type Unit109465459.
- Protein_kinase_domain type Biomolecule.
- Protein_kinase_domain type Protein.
- Protein_kinase_domain type BiologicalObject.
- Protein_kinase_domain comment "The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases. Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation. This functions as an on/off switch for many cellular processes, including metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.".
- Protein_kinase_domain label "Protein kinase domain".
- Protein_kinase_domain sameAs m.03grzrc.
- Protein_kinase_domain sameAs Q7251484.
- Protein_kinase_domain sameAs Q7251484.
- Protein_kinase_domain sameAs Protein_kinase_domain.
- Protein_kinase_domain wasDerivedFrom Protein_kinase_domain?oldid=597351430.
- Protein_kinase_domain depiction PDB_1apm_EBI.jpg.
- Protein_kinase_domain isPrimaryTopicOf Protein_kinase_domain.