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- Purple_acid_phosphatases abstract "Purple acid phosphatases (PAPs) (EC 3.1.3.2) are metalloenzymes that hydrolyse phosphate esters and anhydrides under acidic condition. In their oxidised form, PAPs in solution are purple in colour. This is due to the presence of a dinuclear iron centre, to which a tyrosine residue is connected via a charge transfer. This metallic centre is composed of Fe3+ and M, where M is Fe3+, Zn2+, Mg2+ or Mn2+. The conserved Fe3+ is stabilised in the ferric form, whereas M may undergo reduction. Upon treatment with mild reductants, PAPs are converted to their enzymatically active, pink form. Treatment with strong reducing agents dissociates the metallic ions, and renders the enzyme colourless and inactive.PAPs are highly conserved within eukaryotic species, with >80% amino acid homology in mammalian PAPs, and >70% sequence homology in PAPs of plant origin. However sequence analysis reveals that there is minimal homology between plant and mammal PAPs (<20%), except for the metal-ligating amino acid residues which are identical. The metallic nucleus of PAPs also varies between plants and mammals. Mammalian PAPs which have been isolated and purified have, to this point, been composed exclusively of iron ions, whereas in plants the metallic nucleus is composed of Fe3+ and either Zn2+ or Mn2+. PAPs have also been isolated in fungi, and DNA sequences encoding for possible PAPs have been identified in prokaryotic organisms, such as in Cyanobacteria spp. and Mycobacteria spp.Currently there is no defined nomenclature for this group of enzymes, and a variety of names exists. These include purple acid phosphatase (PAP), uteroferrin (Uf), type 5 acid phosphatase (Acp 5) and tartrate resistant acid phosphatase (TRAP, TRACP, TR-AP). There is, however, a consensus in the literature that purple acid phosphatase (PAP) relates to those found in non-mammalian species and tartrate resistant acid phosphatase (TRAP) to those found in mammalian species.Uteroferrin, bovine spleen PAP and tartrate resistant acid phosphatase all refer to mammalian PAPs, whereby research on PAPs expressed in various tissues diverged. Subsequent research has proven that all of these enzymes are the same entity.".
- Purple_acid_phosphatases wikiPageID "8853581".
- Purple_acid_phosphatases wikiPageRevisionID "592880305".
- Purple_acid_phosphatases hasPhotoCollection Purple_acid_phosphatases.
- Purple_acid_phosphatases subject Category:EC_3.1.3.
- Purple_acid_phosphatases subject Category:Enzymes.
- Purple_acid_phosphatases type Abstraction100002137.
- Purple_acid_phosphatases type Activator114723079.
- Purple_acid_phosphatases type Catalyst114723628.
- Purple_acid_phosphatases type Chemical114806838.
- Purple_acid_phosphatases type Compound114818238.
- Purple_acid_phosphatases type Enzyme114732946.
- Purple_acid_phosphatases type Enzymes.
- Purple_acid_phosphatases type Macromolecule114944888.
- Purple_acid_phosphatases type Material114580897.
- Purple_acid_phosphatases type Matter100020827.
- Purple_acid_phosphatases type Molecule114682133.
- Purple_acid_phosphatases type OrganicCompound114727670.
- Purple_acid_phosphatases type Part113809207.
- Purple_acid_phosphatases type PhysicalEntity100001930.
- Purple_acid_phosphatases type Protein114728724.
- Purple_acid_phosphatases type Relation100031921.
- Purple_acid_phosphatases type Substance100019613.
- Purple_acid_phosphatases type Thing100002452.
- Purple_acid_phosphatases type Unit109465459.
- Purple_acid_phosphatases comment "Purple acid phosphatases (PAPs) (EC 3.1.3.2) are metalloenzymes that hydrolyse phosphate esters and anhydrides under acidic condition. In their oxidised form, PAPs in solution are purple in colour. This is due to the presence of a dinuclear iron centre, to which a tyrosine residue is connected via a charge transfer. This metallic centre is composed of Fe3+ and M, where M is Fe3+, Zn2+, Mg2+ or Mn2+. The conserved Fe3+ is stabilised in the ferric form, whereas M may undergo reduction.".
- Purple_acid_phosphatases label "Purple acid phosphatases".
- Purple_acid_phosphatases sameAs m.027m2l7.
- Purple_acid_phosphatases sameAs Q7261472.
- Purple_acid_phosphatases sameAs Q7261472.
- Purple_acid_phosphatases sameAs Purple_acid_phosphatases.
- Purple_acid_phosphatases wasDerivedFrom Purple_acid_phosphatases?oldid=592880305.
- Purple_acid_phosphatases isPrimaryTopicOf Purple_acid_phosphatases.