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- Pyruvate_decarboxylation abstract "Pyruvate decarboxylation (also known as the Swanson Conversion, oxidative decarboxylation reaction or link reaction) is the far from equilibrium biochemical reaction that uses pyruvate to form acetyl-CoA, releasing NADH, a reducing equivalent, and carbon dioxide via decarboxylation. It is known as the link reaction because it forms an important link between the metabolic pathways of glycolysis and the citric acid cycle. This reaction is usually catalyzed by the pyruvate dehydrogenase complex as part of aerobic respiration. In eukaryotes, pyruvate decarboxylation takes place exclusively inside the mitochondrial matrix; in prokaryotes similar reactions take place in the cytoplasm and at the plasma membrane.This reaction is very common in most organisms as a link to the citric acid cycle. This reaction is carried out in the mitochondria, unlike the reactions of glycolysis which are cytosolic.The conversion of pyruvate to acetyl CoA by the pyruvate dehydrogenase complex is a key step in the liver in particular, as it removes any chance of conversion of pyruvate to glucose, or as a transamination substrate. It commits pyruvate to entering the citric acid cycle, where it is either used as a substrate for oxidative phosphorylation, or is converted to citrate for export to the cytosol to serve as a substrate for fatty acid and isoprenoid biosynthesis.The oxidative decarboxylation of pyruvate in anaerobic organisms differs from the aerobic process in that the electron acceptor is an iron-sulfur protein, not NAD+. The conversion is catalyzed by a thiamine-dependent enzyme that also acylates coenzyme A. The reducing equivalents are disposed of by the production of H2 via hydrogenase.To summarise:1. Pyruvate is decarboxylated 2. It is added to CoA to form Acetyl CoAacetyl CoA is then ready for use in the Krebs cycle.".
- Pyruvate_decarboxylation thumbnail Pyruvate2_wpmp.png?width=300.
- Pyruvate_decarboxylation wikiPageExternalLink pathway.html.
- Pyruvate_decarboxylation wikiPageExternalLink notes-on-pyruvate-metabolism.html.
- Pyruvate_decarboxylation wikiPageID "3221235".
- Pyruvate_decarboxylation wikiPageRevisionID "592201509".
- Pyruvate_decarboxylation forwardEnzyme Pyruvate_dehydrogenase_complex.
- Pyruvate_decarboxylation hasPhotoCollection Pyruvate_decarboxylation.
- Pyruvate_decarboxylation minorForwardProduct(s)_ "CO2 + NADH + H+".
- Pyruvate_decarboxylation minorForwardSubstrate(s)_ "CoA + NAD+".
- Pyruvate_decarboxylation product Acetyl-CoA.
- Pyruvate_decarboxylation productImage "acetyl_co-A_wpmp_small.png".
- Pyruvate_decarboxylation reverse)_ "forward".
- Pyruvate_decarboxylation substrate Pyruvic_acid.
- Pyruvate_decarboxylation substrateImage "Pyruvate2_wpmp.png".
- Pyruvate_decarboxylation subject Category:Cellular_respiration.
- Pyruvate_decarboxylation comment "Pyruvate decarboxylation (also known as the Swanson Conversion, oxidative decarboxylation reaction or link reaction) is the far from equilibrium biochemical reaction that uses pyruvate to form acetyl-CoA, releasing NADH, a reducing equivalent, and carbon dioxide via decarboxylation. It is known as the link reaction because it forms an important link between the metabolic pathways of glycolysis and the citric acid cycle.".
- Pyruvate_decarboxylation label "Decarbossilazione ossidativa del piruvato".
- Pyruvate_decarboxylation label "Décarboxylation du pyruvate".
- Pyruvate_decarboxylation label "Oxidación del piruvato".
- Pyruvate_decarboxylation label "Oxidative Decarboxylierung".
- Pyruvate_decarboxylation label "Pyruvate decarboxylation".
- Pyruvate_decarboxylation label "Reakcja pomostowa".
- Pyruvate_decarboxylation label "丙酮酸脱羧".
- Pyruvate_decarboxylation sameAs Oxidative_Decarboxylierung.
- Pyruvate_decarboxylation sameAs Oxidación_del_piruvato.
- Pyruvate_decarboxylation sameAs Décarboxylation_du_pyruvate.
- Pyruvate_decarboxylation sameAs Decarbossilazione_ossidativa_del_piruvato.
- Pyruvate_decarboxylation sameAs Reakcja_pomostowa.
- Pyruvate_decarboxylation sameAs m.08_9nq.
- Pyruvate_decarboxylation sameAs Q899965.
- Pyruvate_decarboxylation sameAs Q899965.
- Pyruvate_decarboxylation wasDerivedFrom Pyruvate_decarboxylation?oldid=592201509.
- Pyruvate_decarboxylation depiction Pyruvate2_wpmp.png.
- Pyruvate_decarboxylation isPrimaryTopicOf Pyruvate_decarboxylation.