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- R-4066 abstract "R-4066 is a drug which is an analogue of the opioid analgesic methadone, where the metabolically labile dimethylamino group has been replaced by a piperidinospiro group. Developed by Janssen Pharmaceutica, it is around 212x more potent than methadone as an analgesic in animal tests, with an effective oral dosage of 0.07 mg/kg, but is slightly shorter acting, with a duration of action of around 3 hours. If the ketone function is reduced and acetylated, the (R) isomer of the resultant compound is equipotent and has an analgesic duration of 20.5 hours compared to 8 hours for methadone.R-4066 has never been used in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and respiratory depression which could be harmful or fatal.".
- R-4066 casNumber "101564-56-1".
- R-4066 iupacName "6-(3,4-dihydro-1'H,2H-spiro[naphthalene-1,4'-piperidin]-1'-yl)-4,4-diphenylhexan-3-one".
- R-4066 pubchem "380029".
- R-4066 thumbnail R-4066.png?width=300.
- R-4066 wikiPageID "17321403".
- R-4066 wikiPageRevisionID "568181703".
- R-4066 c "32".
- R-4066 casNumber "101564".
- R-4066 h "37".
- R-4066 hasPhotoCollection R-4066.
- R-4066 iupacName "6".
- R-4066 molecularWeight "451.641".
- R-4066 n "1".
- R-4066 o "1".
- R-4066 pubchem "380029".
- R-4066 smiles "CCCCC5=CC=CC=C5".
- R-4066 synonyms "(N--7,8-benzo-3-azaspiro[5.5]undecane)".
- R-4066 verifiedrevid "449870718".
- R-4066 subject Category:Ketones.
- R-4066 subject Category:Mu-opioid_agonists.
- R-4066 subject Category:Nitrogen_heterocycles.
- R-4066 subject Category:Opioids.
- R-4066 subject Category:Spiro_compounds.
- R-4066 type Drug.
- R-4066 type DrugProduct.
- R-4066 type FunctionalSubstance.
- R-4066 comment "R-4066 is a drug which is an analogue of the opioid analgesic methadone, where the metabolically labile dimethylamino group has been replaced by a piperidinospiro group. Developed by Janssen Pharmaceutica, it is around 212x more potent than methadone as an analgesic in animal tests, with an effective oral dosage of 0.07 mg/kg, but is slightly shorter acting, with a duration of action of around 3 hours.".
- R-4066 label "R-4066".
- R-4066 sameAs m.043pxpz.
- R-4066 sameAs Q7273255.
- R-4066 sameAs Q7273255.
- R-4066 wasDerivedFrom R-4066?oldid=568181703.
- R-4066 depiction R-4066.png.
- R-4066 isPrimaryTopicOf R-4066.