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- Ro4-1539 abstract "Ro4-1539 (Furethylnorlevorphanol) is an opioid analgesic drug from the morphinan series that was developed by the pharmaceutical company Hoffmann–La Roche in the 1950s. It acts as a potent μ-opioid agonist, and was found to be around 30-60x more potent than the related drug levorphanol in animal experiments. While it is notable for its high potency and therapeutic index (1100 in animal studies), being among the more potent μ-agonist found in the morphinan series of drugs (though not on the scale of acetorphine and other morphinans in the extremity of their level of potency), Ro4-1539 had no particular clinical advantages over other available opioid drugs, and was never commercially marketed.Ro4-1539 has never been formally trialled in humans, but based on its effects in animals it would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and also respiratory depression, which could be harmful or fatal.".
- Ro4-1539 casNumber "27767-85-7".
- Ro4-1539 iupacName "17-(2-(furan-2-yl)ethyl)-3-hydroxymorphinan".
- Ro4-1539 pubchem "20834001".
- Ro4-1539 thumbnail Furethylnorlevorphanol.svg?width=300.
- Ro4-1539 wikiPageID "21277751".
- Ro4-1539 wikiPageRevisionID "593848679".
- Ro4-1539 c "22".
- Ro4-1539 casNumber "27767".
- Ro4-1539 h "27".
- Ro4-1539 hasPhotoCollection Ro4-1539.
- Ro4-1539 iupacName "17".
- Ro4-1539 molecularWeight "337.454".
- Ro4-1539 n "1".
- Ro4-1539 o "2".
- Ro4-1539 pubchem "20834001".
- Ro4-1539 smiles "C3CCCC1C35c2ccccc2CC1NCCc4ccco4".
- Ro4-1539 verifiedrevid "450105432".
- Ro4-1539 width "240".
- Ro4-1539 subject Category:Furans.
- Ro4-1539 subject Category:Hoffmann-La_Roche.
- Ro4-1539 subject Category:Morphinans.
- Ro4-1539 subject Category:Mu-opioid_agonists.
- Ro4-1539 subject Category:Opioids.
- Ro4-1539 subject Category:Phenols.
- Ro4-1539 type Drug.
- Ro4-1539 type DrugProduct.
- Ro4-1539 type FunctionalSubstance.
- Ro4-1539 comment "Ro4-1539 (Furethylnorlevorphanol) is an opioid analgesic drug from the morphinan series that was developed by the pharmaceutical company Hoffmann–La Roche in the 1950s. It acts as a potent μ-opioid agonist, and was found to be around 30-60x more potent than the related drug levorphanol in animal experiments.".
- Ro4-1539 label "Ro4-1539".
- Ro4-1539 sameAs m.05f5gqb.
- Ro4-1539 sameAs Q7339200.
- Ro4-1539 sameAs Q7339200.
- Ro4-1539 wasDerivedFrom Ro4-1539?oldid=593848679.
- Ro4-1539 depiction Furethylnorlevorphanol.svg.
- Ro4-1539 isPrimaryTopicOf Ro4-1539.