Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Ro48-6791> ?p ?o. }
Showing items 1 to 34 of
34
with 100 items per page.
- Ro48-6791 abstract "Ro48-6791 is a drug, a benzodiazepine derivative developed by Hoffman-LaRoche in the 1990s.Ro48-6791 was developed as an alternative to the short-acting imidazobenzodiazepine midazolam, for use in induction of anaesthesia and conscious sedation for minor invasive procedures. Ro48-6791 has properties similar to those of to midazolam, being water soluble, with a fast onset and short duration of action. It is 4-6x more potent than midazolam, and slightly shorter acting, and produces similar side effects such as sedation and amnesia. It was tested up to Phase II human trials, but while it produced less respiratory depression than propofol, it had a longer recovery time and was deemed not to have any significant advantages over the older drug. Similarly when Ro48-6791 was compared to midazolam, it had similar efficacy, higher potency and a shorter recovery time, but produced less of a synergistic effect on opioid-induced analgesia and produced more severe side effects such as dizziness after the procedure. Consequently it was dropped from clinical development, although it is still used in scientific research.".
- Ro48-6791 iupacName "3-{5-[(dipropylamino)methyl]- 1,2,4-oxadiazol-3-yl}- 8-fluoro- 5-methyl- 4,5-dihydro- 6H-imidazo[1,5-a] [1,4]benzodiazepin- 6-one".
- Ro48-6791 pubchem "9953485".
- Ro48-6791 thumbnail Ro48-6791.svg?width=300.
- Ro48-6791 wikiPageID "16303716".
- Ro48-6791 wikiPageRevisionID "600897792".
- Ro48-6791 c "21".
- Ro48-6791 f "1".
- Ro48-6791 h "25".
- Ro48-6791 hasPhotoCollection Ro48-6791.
- Ro48-6791 iupacName "3".
- Ro48-6791 molecularWeight "412.47".
- Ro48-6791 n "6".
- Ro48-6791 o "2".
- Ro48-6791 pubchem "9953485".
- Ro48-6791 verifiedrevid "448075259".
- Ro48-6791 width "200".
- Ro48-6791 subject Category:Benzodiazepines.
- Ro48-6791 subject Category:Hoffmann-La_Roche.
- Ro48-6791 subject Category:Imidazobenzodiazepines.
- Ro48-6791 subject Category:Lactams.
- Ro48-6791 subject Category:Organofluorides.
- Ro48-6791 subject Category:Oxadiazoles.
- Ro48-6791 type Drug.
- Ro48-6791 type DrugProduct.
- Ro48-6791 type FunctionalSubstance.
- Ro48-6791 comment "Ro48-6791 is a drug, a benzodiazepine derivative developed by Hoffman-LaRoche in the 1990s.Ro48-6791 was developed as an alternative to the short-acting imidazobenzodiazepine midazolam, for use in induction of anaesthesia and conscious sedation for minor invasive procedures. Ro48-6791 has properties similar to those of to midazolam, being water soluble, with a fast onset and short duration of action.".
- Ro48-6791 label "Ro48-6791".
- Ro48-6791 sameAs m.03wgfzp.
- Ro48-6791 sameAs Q7339202.
- Ro48-6791 sameAs Q7339202.
- Ro48-6791 wasDerivedFrom Ro48-6791?oldid=600897792.
- Ro48-6791 depiction Ro48-6791.svg.
- Ro48-6791 isPrimaryTopicOf Ro48-6791.