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- S-14,671 abstract "S-14,671 is a naphthylpiperazine derivative which acts as a 5-HT1A receptor agonist (pKi = 9.3) with high efficacy and exceptional in vivo potency, and also as a 5-HT2A and 5-HT2C receptor antagonist (both are pKi = 7.8). It displays only low and non-significant affinity for 5-HT1B and 5-HT3 sites.In producing 5-HT1A-mediated effects such as hypothermia and spontaneous tail flicks in rodents, S-14,671 is active at doses as low as 5 µg subcutaneously, and is about 10-fold more potent than 8-OH-DPAT and 100-fold more potent than flesinoxan and buspirone. Other 5-HT1A-mediated effects of S-14,671 include induction of flat-body posture, corticosterone secretion, inhibition of morphine-induced antinociception, and attenuation of the electrical activity of the dorsal raphe nucleus.S-14,671 has been found to possess powerful efficacy in the rodent forced swim test and in the pigeon conflict test, indicating marked antidepressant and anxiolytic effects, respectively, of which are also 5-HT1A-mediated. It has never been trialed in humans, perhaps due to its potency being too great.[citation needed]".
- S-14,671 atcPrefix "none".
- S-14,671 casNumber "135722-27-9".
- S-14,671 iupacName "N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}thiophene-2-carboxamide".
- S-14,671 pubchem "131907".
- S-14,671 thumbnail S-14671-structure.png?width=300.
- S-14,671 wikiPageID "28482815".
- S-14,671 wikiPageRevisionID "592967732".
- S-14,671 atcPrefix "none".
- S-14,671 c "22".
- S-14,671 casNumber "135722".
- S-14,671 chemspiderid "116529".
- S-14,671 h "25".
- S-14,671 hasPhotoCollection S-14,671.
- S-14,671 iupacName "N-{2-[4-piperazin-1-yl]ethyl}thiophene-2-carboxamide".
- S-14,671 molecularWeight "395.52".
- S-14,671 n "3".
- S-14,671 o "2".
- S-14,671 pubchem "131907".
- S-14,671 s "1".
- S-14,671 subject Category:Carboxamides.
- S-14,671 subject Category:Naphthol_ethers.
- S-14,671 subject Category:Phenol_ethers.
- S-14,671 subject Category:Piperazines.
- S-14,671 subject Category:Thiophenes.
- S-14,671 type Drug.
- S-14,671 type FunctionalSubstance.
- S-14,671 comment "S-14,671 is a naphthylpiperazine derivative which acts as a 5-HT1A receptor agonist (pKi = 9.3) with high efficacy and exceptional in vivo potency, and also as a 5-HT2A and 5-HT2C receptor antagonist (both are pKi = 7.8).".
- S-14,671 label "S-14,671".
- S-14,671 sameAs m.0crhbd2.
- S-14,671 sameAs Q7387033.
- S-14,671 sameAs Q7387033.
- S-14,671 wasDerivedFrom S-14,671?oldid=592967732.
- S-14,671 depiction S-14671-structure.png.
- S-14,671 isPrimaryTopicOf S-14,671.