Matches in DBpedia 2014 for { <http://dbpedia.org/resource/SCH-50911> ?p ?o. }
Showing items 1 to 25 of
25
with 100 items per page.
- SCH-50911 abstract "SCH-50911 is a selective GABAB antagonist developed by Schering-Plough Corporation. Its main applications are in pharmacology research, but it has been found to quickly and effectively reverse the symptoms of GHB overdose in mice. In one experiment, mice were given a lethal dose of GHB (7000 mg/kg) followed by varying doses of SCH-50911. At the two higher doses of the antagonist (150 mg/kg and 300 mg/kg), only 2 out of 20 of the mice died (10%), compared to 100% lethality in the control group.SCH-50911 also acts as an anticonvulsant under normal conditions, and so counteracts both the depressant and pro-convulsant effects of GHB overdose. This pharmacological profile makes SCH-50911 a promising candidate as a GHB antidote for human use, and might also make it useful for treating overdoses of other GABAB agonists such as Baclofen. SCH-50911 has never been tested for this purpose in humans and there are no plans at this stage to develop it for these applications. However SCH-50911 induces acute withdrawal syndrome in GHB-dependent rats, similar to the delirium tremens seen in human alcohol withdrawal, and can precipitate convulsions in GHB-dependent animals.This means that while SCH-50911 is likely to be a useful antidote for GHB overdose in non-addicted individuals, its use in people who are dependent on GHB or its analogues could be potentially dangerous as it might precipitate acute withdrawal symptoms, and additional anticonvulsants such as diazepam would most likely be required to counteract the risk of life-threatening seizures. This is similar to the problems seen with opioid antagonists such as naloxone, which are useful antidotes to opiate overdose but may precipitate acute withdrawal syndrome in opiate-addicted individuals.".
- SCH-50911 iupacName "2-[(2S)-5,5-dimethylmorpholin-2-yl]acetic acid".
- SCH-50911 thumbnail SCH-50911.svg?width=300.
- SCH-50911 wikiPageID "9062395".
- SCH-50911 wikiPageRevisionID "586668423".
- SCH-50911 hasPhotoCollection SCH-50911.
- SCH-50911 imagefile "SCH-50911.svg".
- SCH-50911 iupacname "2".
- SCH-50911 verifiedrevid "401047434".
- SCH-50911 subject Category:Antidotes.
- SCH-50911 subject Category:Carboxylic_acids.
- SCH-50911 subject Category:Morpholines.
- SCH-50911 type ChemicalCompound.
- SCH-50911 type ChemicalSubstance.
- SCH-50911 type ChemicalSubstanceType.
- SCH-50911 type ChemicalObject.
- SCH-50911 type Thing.
- SCH-50911 comment "SCH-50911 is a selective GABAB antagonist developed by Schering-Plough Corporation. Its main applications are in pharmacology research, but it has been found to quickly and effectively reverse the symptoms of GHB overdose in mice. In one experiment, mice were given a lethal dose of GHB (7000 mg/kg) followed by varying doses of SCH-50911.".
- SCH-50911 label "SCH-50911".
- SCH-50911 sameAs m.027w8r2.
- SCH-50911 sameAs Q7389135.
- SCH-50911 sameAs Q7389135.
- SCH-50911 wasDerivedFrom SCH-50911?oldid=586668423.
- SCH-50911 depiction SCH-50911.svg.
- SCH-50911 isPrimaryTopicOf SCH-50911.