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- STAT5A abstract "Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. STAT5A orthologs have been identified in several placentals for which complete genome data are available.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.".
- STAT5A entrezgene "6776".
- STAT5A wikiPageID "14150957".
- STAT5A wikiPageRevisionID "602178290".
- STAT5A hasPhotoCollection STAT5A.
- STAT5A requireManualInspection "no".
- STAT5A summaryText "The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X, which suggests the antiapoptotic function of this gene in cells.".
- STAT5A updateCitations "yes".
- STAT5A updatePage "yes".
- STAT5A updateProteinBox "yes".
- STAT5A updateSummary "yes".
- STAT5A subject Category:Transcription_factors.
- STAT5A type Biomolecule.
- STAT5A type Protein.
- STAT5A type BiologicalObject.
- STAT5A comment "Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. STAT5A orthologs have been identified in several placentals for which complete genome data are available.The protein encoded by this gene is a member of the STAT family of transcription factors.".
- STAT5A label "STAT5A".
- STAT5A label "STAT5A".
- STAT5A sameAs STAT5A.
- STAT5A sameAs m.03cw4z8.
- STAT5A sameAs Q7394694.
- STAT5A sameAs Q7394694.
- STAT5A wasDerivedFrom STAT5A?oldid=602178290.
- STAT5A isPrimaryTopicOf STAT5A.