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- Salvinorin_B_ethoxymethyl_ether abstract "Salvinorin B ethoxymethyl ether (2-O-ethoxymethylsalvinorin B, symmetry) is a semi-synthetic analogue of the natural product salvinorin A, with a longer duration of action of around 3 hours (compared to less than 30 minutes for salvinorin A), and increased affinity and intrinsic activity at the κ-opioid receptor. Like the related compound herkinorin, 2-ethoxymethyl salvinorin B is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities.Salvinorin B ethoxymethyl ether has a Ki of 0.32 nM at the κ-opioid receptor, and around 3,000 times selectivity over the μ- and δ-opioid receptors, making it one of the most potent and selective kappa agonists yet discovered. In animal studies it fully substituted for salvinorin A and the synthetic kappa agonist U-69593, and was active at doses as low as 0.005 mg/kg. Human bioassays found the compound to be active at 50 μg.".
- Salvinorin_B_ethoxymethyl_ether atcPrefix "none".
- Salvinorin_B_ethoxymethyl_ether iupacName "(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(ethoxymethoxy)-2-(3-furanyl)dodecahydro -6a,10b-dimethyl-4,10-dioxo-2H-naphtho-[2,1-c]pyran-7-carboxylic acid methyl ester".
- Salvinorin_B_ethoxymethyl_ether pubchem "24873526".
- Salvinorin_B_ethoxymethyl_ether thumbnail 2-EtOMeSalB.png?width=300.
- Salvinorin_B_ethoxymethyl_ether wikiPageID "23357446".
- Salvinorin_B_ethoxymethyl_ether wikiPageRevisionID "597221234".
- Salvinorin_B_ethoxymethyl_ether atcPrefix "none".
- Salvinorin_B_ethoxymethyl_ether c "24".
- Salvinorin_B_ethoxymethyl_ether chembl "272939".
- Salvinorin_B_ethoxymethyl_ether chemspiderid "23323659".
- Salvinorin_B_ethoxymethyl_ether h "32".
- Salvinorin_B_ethoxymethyl_ether hasPhotoCollection Salvinorin_B_ethoxymethyl_ether.
- Salvinorin_B_ethoxymethyl_ether inchi "1".
- Salvinorin_B_ethoxymethyl_ether inchikey "ICVTXAUKIHJDGV-WFOQEEKOBW".
- Salvinorin_B_ethoxymethyl_ether iupacName "-9".
- Salvinorin_B_ethoxymethyl_ether legalStatus "Legal/Uncontrolled".
- Salvinorin_B_ethoxymethyl_ether molecularWeight "448.505".
- Salvinorin_B_ethoxymethyl_ether o "8".
- Salvinorin_B_ethoxymethyl_ether pubchem "24873526".
- Salvinorin_B_ethoxymethyl_ether smiles "CCOCO[C@H]1C[C@H]COC".
- Salvinorin_B_ethoxymethyl_ether stdinchi "1".
- Salvinorin_B_ethoxymethyl_ether stdinchikey "ICVTXAUKIHJDGV-WFOQEEKOSA-N".
- Salvinorin_B_ethoxymethyl_ether verifiedrevid "414178678".
- Salvinorin_B_ethoxymethyl_ether width "200".
- Salvinorin_B_ethoxymethyl_ether subject Category:Dissociative_drugs.
- Salvinorin_B_ethoxymethyl_ether subject Category:Ethers.
- Salvinorin_B_ethoxymethyl_ether subject Category:Furans.
- Salvinorin_B_ethoxymethyl_ether subject Category:Kappa_agonists.
- Salvinorin_B_ethoxymethyl_ether subject Category:Lactones.
- Salvinorin_B_ethoxymethyl_ether subject Category:Naphthopyrans.
- Salvinorin_B_ethoxymethyl_ether subject Category:Semisynthetic_opioids.
- Salvinorin_B_ethoxymethyl_ether type Drug.
- Salvinorin_B_ethoxymethyl_ether type FunctionalSubstance.
- Salvinorin_B_ethoxymethyl_ether comment "Salvinorin B ethoxymethyl ether (2-O-ethoxymethylsalvinorin B, symmetry) is a semi-synthetic analogue of the natural product salvinorin A, with a longer duration of action of around 3 hours (compared to less than 30 minutes for salvinorin A), and increased affinity and intrinsic activity at the κ-opioid receptor.".
- Salvinorin_B_ethoxymethyl_ether label "Salvinorin B ethoxymethyl ether".
- Salvinorin_B_ethoxymethyl_ether sameAs m.06w9vz3.
- Salvinorin_B_ethoxymethyl_ether sameAs Q2118147.
- Salvinorin_B_ethoxymethyl_ether sameAs Q2118147.
- Salvinorin_B_ethoxymethyl_ether wasDerivedFrom Salvinorin_B_ethoxymethyl_ether?oldid=597221234.
- Salvinorin_B_ethoxymethyl_ether depiction 2-EtOMeSalB.png.
- Salvinorin_B_ethoxymethyl_ether isPrimaryTopicOf Salvinorin_B_ethoxymethyl_ether.