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- Saridegib abstract "Saridegib also known as IPI-926 is an experimental drug candidate undergoing clinical trials for the treatment of various types of cancer, including hard to treat hematologic malignancies such as myelofibrosis and ligand-dependant tumors such as chondrosarcoma. IPI-926 exhibits its pharmacological effect by inhibition of the G protein-coupled receptor smoothened, a component of the hedgehog signaling pathway. Chemically, it is a semi-synthetic derivative of the alkaloid cyclopamine. The process begins with cyclopamine extracted from harvested Veratrum californicum which is taken through a series of alterations resulting in an analogue of the natural product cyclopamine, making IPI-926 the only compound in development/testing that is not fully synthetic.".
- Saridegib iupacName "N-((2S,3R,3aS,3′R,4a′R,6S,6a′R,6b′S,7aR,12a&prmie;S,12b′S)-3,6,11′,12b′-tetramethyl-2′,3a,3′,4,4′,4a′,5,5&prmie;,6,6′,6a′,6b′,7,7a,7′,8′,10′,12′,12a′,12b′-icosahydro-1′H,3H-spiro[furo[3,2-b]pyridine-2,9'-naphtho[2,1-a]azulen]-3'-yl)methanesulfonamide".
- Saridegib thumbnail Saridegib.svg?width=300.
- Saridegib wikiPageID "32466511".
- Saridegib wikiPageRevisionID "596721986".
- Saridegib date "February 2014".
- Saridegib imagefile "Saridegib.svg".
- Saridegib imagefile "Saridegib3Dan.gif".
- Saridegib imagesize "200".
- Saridegib iupacname "N-methanesulfonamide".
- Saridegib iupacnameHidden "yes".
- Saridegib legalstatus "Investigational".
- Saridegib othernames "saridegib".
- Saridegib reason "this details about the general class of compounds isn't terribly relevant here - maybe start hedgehog inhibitor article, or move this content to hedgehog signaling pathway".
- Saridegib routesofadministration "Oral".
- Saridegib verifiedrevid "443867582".
- Saridegib subject Category:Cell_signaling.
- Saridegib subject Category:G_protein_coupled_receptors.
- Saridegib subject Category:Human_proteins.
- Saridegib subject Category:Jervines.
- Saridegib subject Category:Ligands.
- Saridegib subject Category:Morphogens.
- Saridegib subject Category:Spiro_compounds.
- Saridegib subject Category:Sulfonamides.
- Saridegib type ChemicalCompound.
- Saridegib type ChemicalSubstance.
- Saridegib type ChemicalObject.
- Saridegib type Thing.
- Saridegib comment "Saridegib also known as IPI-926 is an experimental drug candidate undergoing clinical trials for the treatment of various types of cancer, including hard to treat hematologic malignancies such as myelofibrosis and ligand-dependant tumors such as chondrosarcoma. IPI-926 exhibits its pharmacological effect by inhibition of the G protein-coupled receptor smoothened, a component of the hedgehog signaling pathway. Chemically, it is a semi-synthetic derivative of the alkaloid cyclopamine.".
- Saridegib label "Saridegib".
- Saridegib sameAs m.0h1g57v.
- Saridegib sameAs Q15426668.
- Saridegib sameAs Q15426668.
- Saridegib wasDerivedFrom Saridegib?oldid=596721986.
- Saridegib depiction Saridegib.svg.
- Saridegib isPrimaryTopicOf Saridegib.