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- Shinya_Inoué abstract "Shinya Inoué (井上 信也, Inoue Shin'ya, born 1921) is a Japanese-born American biophysicist and cell biologist, a member of the National Academy of Sciences. His research field is the visualization of dynamic processes within living cells using light microscopy. Currently he is a researcher at the Marine Biological Laboratory.Inoue can be considered the father of the field of cytoskeleton dynamics. In the 1940s and 50s he built the first microscope capable of imaging dynamic processes in live cells, using polarized light, and proved for the first time that the mitotic spindle is composed of aligned protein fibers. We now know these fibers are microtubules. By perturbing cells with agents that cause microtubules to depolymerize (e.g. colchicine or high pressure) or polymerize excessively (e.g. D2O), Inoue demonstrated that spindle fibers are in a state of rapid dynamic equilibrium with a pool of soluble subunits in the cytoplasm. He went on to show that artificial polymerization and depolymerization of spindle fibers can generate forces within the cell, and proposed that chromosomes are normally moved by such forces during mitosis. These ideas were summarized in a seminal review in 1967. He also was the first to develop video microscopy, and wrote a major textbook on the subject. Consistent with Inoue's pioneering ideas, it is now widely believed that chromosome movement during mitosis is powered by microtubule depolymerization. We also know that force generation by polymerization and depolymerization of cytoskeletal protein fibers is perhaps the most ancient of motile mechanisms within cells, whose use extends back to bacteria.".
- Shinya_Inoué wikiPageID "21156534".
- Shinya_Inoué wikiPageRevisionID "596623070".
- Shinya_Inoué name "Inoue, Shinya".
- Shinya_Inoué shortDescription "American scientist".
- Shinya_Inoué description "American scientist".
- Shinya_Inoué subject Category:1921_births.
- Shinya_Inoué subject Category:American_academics_of_Japanese_descent.
- Shinya_Inoué subject Category:American_biophysicists.
- Shinya_Inoué subject Category:American_people_of_Japanese_descent.
- Shinya_Inoué subject Category:Cell_biologists.
- Shinya_Inoué subject Category:Japanese_biologists.
- Shinya_Inoué subject Category:Japanese_biophysicists.
- Shinya_Inoué subject Category:Japanese_emigrants_to_the_United_States.
- Shinya_Inoué subject Category:Japanese_scientists.
- Shinya_Inoué subject Category:Living_people.
- Shinya_Inoué subject Category:Members_of_the_United_States_National_Academy_of_Sciences.
- Shinya_Inoué subject Category:Princeton_University_alumni.
- Shinya_Inoué subject Category:University_of_Tokyo_alumni.
- Shinya_Inoué type Agent.
- Shinya_Inoué type Person.
- Shinya_Inoué type Person.
- Shinya_Inoué type Q215627.
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- Shinya_Inoué comment "Shinya Inoué (井上 信也, Inoue Shin'ya, born 1921) is a Japanese-born American biophysicist and cell biologist, a member of the National Academy of Sciences. His research field is the visualization of dynamic processes within living cells using light microscopy. Currently he is a researcher at the Marine Biological Laboratory.Inoue can be considered the father of the field of cytoskeleton dynamics.".
- Shinya_Inoué label "Shinya Inoué".
- Shinya_Inoué label "Shinya Inoué".
- Shinya_Inoué label "井上信也".
- Shinya_Inoué sameAs Shinya_Inou%C3%A9.
- Shinya_Inoué sameAs Shinya_Inoué.
- Shinya_Inoué sameAs 井上信也.
- Shinya_Inoué sameAs Q1516739.
- Shinya_Inoué sameAs Q1516739.
- Shinya_Inoué wasDerivedFrom Shinya_Inoué?oldid=596623070.
- Shinya_Inoué givenName "Shinya".
- Shinya_Inoué name "Shinya Inoue".
- Shinya_Inoué surname "Inoue".