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- Sialoadhesin abstract "Sialoadhesin is a cell adhesion molecule found on the surface of certain cells of the immune system called macrophages. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, colon, and lungs. Also, in patients suffering from rheumatoid arthritis, the protein has been found in great amounts on macrophages of the affected tissues. It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF). Sialoadhesin binds to certain molecules called sialic acids. During this binding process a salt bridge (protein) is formed between a highly conserved arginine residue (from the v-set domain to the 3'-sialyllactose) and the carboxylate group of the sialic acid. Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. Alternate names for sialoadhesin include siglec-1 and CD169 (cluster of differentiation 169).Sialoadhesin predominately binds neutrophils, but can also bind monocytes, natural killer cells, B cells and a subset of cytotoxic T cells by interacting with sialic acid molecules in the ligands on their surfaces.Sialaodhesin (CD169) positive macrophages, along with mesenchymal stem cells and beta-adrenergic neurons, form the hematopoietic stem cell niche in the bone marrow. CD169+ macrophages mediate signaling between the various cells and seem to promote hematopoietic stem cell retention to the niche.".
- Sialoadhesin arm "p".
- Sialoadhesin band "13".
- Sialoadhesin chromosome "20".
- Sialoadhesin entrezgene "6614".
- Sialoadhesin hgncid "11127".
- Sialoadhesin omim "600751".
- Sialoadhesin pdb "2BVE".
- Sialoadhesin refseq "NM_023068".
- Sialoadhesin symbol "SIGLEC1".
- Sialoadhesin symbol "SN, CD169".
- Sialoadhesin thumbnail 2BVE.pdb.jpg?width=300.
- Sialoadhesin uniprot "Q9BZZ2".
- Sialoadhesin wikiPageID "9718203".
- Sialoadhesin wikiPageRevisionID "596904002".
- Sialoadhesin altsymbols "SN, CD169".
- Sialoadhesin arm "p".
- Sialoadhesin band "13".
- Sialoadhesin caption "Structure of the N-terimal domain of mouse sialoadhesin.".
- Sialoadhesin chromosome "20".
- Sialoadhesin entrezgene "6614".
- Sialoadhesin hasPhotoCollection Sialoadhesin.
- Sialoadhesin hgncid "11127".
- Sialoadhesin name "Sialoadhesin".
- Sialoadhesin omim "600751".
- Sialoadhesin pdb "2".
- Sialoadhesin refseq "NM_023068".
- Sialoadhesin symbol "SIGLEC1".
- Sialoadhesin uniprot "Q9BZZ2".
- Sialoadhesin subject Category:Clusters_of_differentiation.
- Sialoadhesin subject Category:SIGLEC.
- Sialoadhesin type Abstraction100002137.
- Sialoadhesin type Agglomeration107959269.
- Sialoadhesin type Bunch107959943.
- Sialoadhesin type ClustersOfDifferentiation.
- Sialoadhesin type Collection107951464.
- Sialoadhesin type Group100031264.
- Sialoadhesin type Biomolecule.
- Sialoadhesin type Protein.
- Sialoadhesin type ProteinMolecule.
- Sialoadhesin type BiologicalObject.
- Sialoadhesin comment "Sialoadhesin is a cell adhesion molecule found on the surface of certain cells of the immune system called macrophages. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, colon, and lungs. Also, in patients suffering from rheumatoid arthritis, the protein has been found in great amounts on macrophages of the affected tissues.".
- Sialoadhesin label "Sialoadhesin".
- Sialoadhesin sameAs m.02pq1qy.
- Sialoadhesin sameAs Q7506686.
- Sialoadhesin sameAs Q7506686.
- Sialoadhesin sameAs Sialoadhesin.
- Sialoadhesin wasDerivedFrom Sialoadhesin?oldid=596904002.
- Sialoadhesin depiction 2BVE.pdb.jpg.
- Sialoadhesin isPrimaryTopicOf Sialoadhesin.
- Sialoadhesin name "Sialoadhesin".