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- Simon_Boulton abstract "Simon Joseph Boulton is a an award-winning British scientist who has made major contributions to the understanding of DNA repair and the treatment of cancer resulting from DNA damage. He currently occupies the position of Senior Research Scientist and group leader of the DNA Damage Response (DDR) Laboratory at Cancer Research UK, London Research Institute, Clare Hall Laboratories. He is also an honorary Professor at University College London.The website of Cancer Research UK explains Boulton's work in this way: human DNA “is constantly under assault from chemical reactions taking place in our bodies and from things we're exposed to in our everyday lives....Most of the time, DNA damage is repaired successfully by the cell. But if the cell continues to grow whilst its DNA is already damaged, it can lead to cancer.” Boulton is learning about DNA damage repair “by first studying it inside a microscopic worm called C. elegans and then extending these findings to human cells,” an approach that has revealed “remarkable similarities between the genes and proteins used to repair DNA damage in the worm and in humans....By studying this fundamental process of DNA damage repair, the researchers have contributed to our understanding of how faults in the system can lead to cancer.”Boulton himself has explained his work at the DNA Damage Response Laboratory as follows: “DNA is a highly reactive molecule that is susceptible to damage. Fortunately, cells have evolved specialised repair processes that are remarkably efficient in correcting specific types of DNA damage. Failure to correctly repair DNA damage will lead to mutagenic change, which can contribute to ageing and cancer. Indeed, defects in genes that repair DNA damage are the underlying cause of a number of hereditary ageing/cancer predisposition syndromes such as Fanconi anemia and Blooms. The focus of my lab is to identify new DNA repair genes, understand how they work in DNA repair in mitotic and meiotic cells and determine how defects in these processes contribute to human disease such as cancer. We hope that our work will provide an improved understanding of how DNA repair works and how, when DNA repair is compromised, it contributes to cancer/ageing and or infertility disorders in humans.” Boulton's research has resulted in several major breakthroughs in understanding that are viewed as highly promising with regard to the potential development of new cancer treatments.".
- Simon_Boulton almaMater University_of_Cambridge.
- Simon_Boulton almaMater University_of_Edinburgh.
- Simon_Boulton award European_Molecular_Biology_Organization.
- Simon_Boulton award Royal_Society.
- Simon_Boulton birthDate "1972".
- Simon_Boulton birthName "Simon Joseph Boulton".
- Simon_Boulton birthYear "1972".
- Simon_Boulton thumbnail DNA_Repair.jpg?width=300.
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- Simon_Boulton academicAdvisors "Marc Vidal".
- Simon_Boulton academicAdvisors "Nick Dyson".
- Simon_Boulton almaMater University_of_Cambridge.
- Simon_Boulton almaMater University_of_Edinburgh.
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- Simon_Boulton awards "EMBO Gold Medal".
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- Simon_Boulton birthName "Simon Joseph Boulton".
- Simon_Boulton dateOfBirth "1972".
- Simon_Boulton doctoralAdvisor "Steve P. Jackson".
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- Simon_Boulton name "Boulton, Simon".
- Simon_Boulton name "Professor Simon Boulton".
- Simon_Boulton shortDescription "British scientist".
- Simon_Boulton thesisTitle "The functional characterisation of Ku in the budding yeast, Saccharomyces cerevisiae".
- Simon_Boulton thesisUrl holdingsInfo?bibId=19511.
- Simon_Boulton thesisYear "1998".
- Simon_Boulton workplaces Gurdon_Institute.
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- Simon_Boulton workplaces University_College_London.
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- Simon_Boulton description "British scientist".
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- Simon_Boulton comment "Simon Joseph Boulton is a an award-winning British scientist who has made major contributions to the understanding of DNA repair and the treatment of cancer resulting from DNA damage. He currently occupies the position of Senior Research Scientist and group leader of the DNA Damage Response (DDR) Laboratory at Cancer Research UK, London Research Institute, Clare Hall Laboratories.".
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