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- Small_molecule_drug_conjugate abstract "Small molecule drug conjugates or SMDCs are built with three modules: a targeting ligand, a linker and a drug payload. The targeting ligands consist of low molecular weight, high-affinity ligands that are precisely linked to potent drugs. The linkers are designed to be stable in the bloodstream and then release the active drug from the targeting ligand when the SMDC is taken up by the diseased cell. The drug payloads are highly active molecules that are too toxic to be administered in their untargeted forms at therapeutic dose levels. This modular approach allows varying targeting ligands, linker systems and drug payloads and generate SMDCs for different diseases.The most advanced SMDC is vintafolide, a derivative of the anti-mitotic chemotherapy drug vinblastine which is chemically linked to folic acid.SMDCs are currently being developed by Endocyte for treating cancer, inflammatory diseases and kidney disease, as well as a companion imaging agent that is created by replacing the potent drug with an imaging agent.".
- Small_molecule_drug_conjugate wikiPageID "40943457".
- Small_molecule_drug_conjugate wikiPageRevisionID "580095032".
- Small_molecule_drug_conjugate subject Category:Drug_delivery_devices.
- Small_molecule_drug_conjugate comment "Small molecule drug conjugates or SMDCs are built with three modules: a targeting ligand, a linker and a drug payload. The targeting ligands consist of low molecular weight, high-affinity ligands that are precisely linked to potent drugs. The linkers are designed to be stable in the bloodstream and then release the active drug from the targeting ligand when the SMDC is taken up by the diseased cell.".
- Small_molecule_drug_conjugate label "Small molecule drug conjugate".
- Small_molecule_drug_conjugate sameAs m.0yt147b.
- Small_molecule_drug_conjugate sameAs Q17037259.
- Small_molecule_drug_conjugate sameAs Q17037259.
- Small_molecule_drug_conjugate wasDerivedFrom Small_molecule_drug_conjugate?oldid=580095032.
- Small_molecule_drug_conjugate isPrimaryTopicOf Small_molecule_drug_conjugate.