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- Sofosbuvir abstract "Sofosbuvir (brand name Sovaldi) is a drug used for hepatitis C infection, with a high cure rate. It inhibits the RNA polymerase that the hepatitis C virus (HCV) uses to replicate its RNA. It was discovered at Pharmasset and developed by Gilead Sciences.Sofosbuvir is a component of the first all-oral, interferon-free regimen approved for treating chronic hepatitis C. Interferon-free therapy for treatment of hepatitis C reduces the side effects associated with use of interferon.In 2013, the Food and Drug Administration (FDA) approved sofosbuvir in combination with ribavirin (RBV) for oral dual therapy of HCV genotypes 2 and 3, and for triple therapy with injected pegylated interferon (pegIFN) and RBV for treatment-naive patients with HCV genotypes 1 and 4. Sofosbuvir treatment regimens last 12 weeks for genotypes 1, 2 and 4, and 24 weeks for treatment of genotype 3. This is typically half the time as with prior treatments. The label further states that sofosbuvir in combination with ribavirin may be considered for patients infected with genotype 1 who are interferon-ineligible.The price of sofosbuvir, quoted in various media sources as $84,000 to $168,000 for a course of treatment in the U.S. and £35,000 for 12 weeks in the UK, has engendered considerable controversy, particularly with respect to accessibility in developing countries.".
- Sofosbuvir atcPrefix "J05".
- Sofosbuvir atcSuffix "AB".
- Sofosbuvir casNumber "1190307-88-0".
- Sofosbuvir fdaUniiCode "WJ6CA3ZU8B".
- Sofosbuvir iupacName "Isopropyl (2S)-2-[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate".
- Sofosbuvir pubchem "45375808".
- Sofosbuvir thumbnail Sofosbuvir_structure.svg?width=300.
- Sofosbuvir wikiPageID "33832492".
- Sofosbuvir wikiPageRevisionID "606108480".
- Sofosbuvir atcPrefix "J05".
- Sofosbuvir atcSuffix "AB".
- Sofosbuvir c "22".
- Sofosbuvir casNumber "1190307".
- Sofosbuvir chembl "1259059".
- Sofosbuvir chemspiderid "26286922".
- Sofosbuvir eliminationHalfLife "1440.0".
- Sofosbuvir eliminationHalfLife "97200.0".
- Sofosbuvir excretion "80".
- Sofosbuvir f "1".
- Sofosbuvir h "29".
- Sofosbuvir hasPhotoCollection Sofosbuvir.
- Sofosbuvir inchi "1".
- Sofosbuvir inchikey "TTZHDVOVKQGIBA-IQWMDFIBBF".
- Sofosbuvir iupacName "Isopropyl -2-[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate".
- Sofosbuvir kegg "D10366".
- Sofosbuvir legalUs "Rx-only".
- Sofosbuvir licenceUs "Sofosbuvir".
- Sofosbuvir metabolism "Quickly activated to triphosphate".
- Sofosbuvir molecularWeight "529.453".
- Sofosbuvir n "3".
- Sofosbuvir o "9".
- Sofosbuvir p "1".
- Sofosbuvir pregnancyUs "B".
- Sofosbuvir proteinBound "61".
- Sofosbuvir pubchem "45375808".
- Sofosbuvir smiles "C[C@@H]N[P@]Oc3ccccc3".
- Sofosbuvir stdinchi "1".
- Sofosbuvir stdinchikey "TTZHDVOVKQGIBA-IQWMDFIBSA-N".
- Sofosbuvir synonyms "PSI-7977; GS-7977".
- Sofosbuvir tradename "Sovaldi".
- Sofosbuvir unii "WJ6CA3ZU8B".
- Sofosbuvir subject Category:Anti-RNA_virus_drugs.
- Sofosbuvir subject Category:Hepatitis_C.
- Sofosbuvir subject Category:Organofluorides.
- Sofosbuvir subject Category:Prodrugs.
- Sofosbuvir subject Category:Propionates.
- Sofosbuvir subject Category:Pyrimidinediones.
- Sofosbuvir type Drug.
- Sofosbuvir type FunctionalSubstance.
- Sofosbuvir comment "Sofosbuvir (brand name Sovaldi) is a drug used for hepatitis C infection, with a high cure rate. It inhibits the RNA polymerase that the hepatitis C virus (HCV) uses to replicate its RNA. It was discovered at Pharmasset and developed by Gilead Sciences.Sofosbuvir is a component of the first all-oral, interferon-free regimen approved for treating chronic hepatitis C.".
- Sofosbuvir label "Sofosbuvir".
- Sofosbuvir label "Sofosbuvir".
- Sofosbuvir label "Sofosbuvir".
- Sofosbuvir label "Sofosbuvir".
- Sofosbuvir sameAs Sofosbuvir.
- Sofosbuvir sameAs Sofosbuvir.
- Sofosbuvir sameAs Sofosbuvir.
- Sofosbuvir sameAs Sofosbuvir.
- Sofosbuvir sameAs m.0hncg8p.
- Sofosbuvir sameAs Q2502747.
- Sofosbuvir sameAs Q2502747.
- Sofosbuvir wasDerivedFrom Sofosbuvir?oldid=606108480.
- Sofosbuvir depiction Sofosbuvir_structure.svg.
- Sofosbuvir isPrimaryTopicOf Sofosbuvir.