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- Sterile_alpha_motif abstract "In molecular biology, the protein domain Sterile alpha motif (or SAM) is a putative protein interaction module present in a wide variety of proteins involved in many biological processes. The SAM domain that spreads over around 70 residues is found in diverse eukaryotic organisms. SAM domains have been shown to homo- and hetero-oligomerise, forming multiple self-association architectures and also binding to various non-SAM domain-containing proteins, nevertheless with a low affinity constant.SAM domains also appear to possess the ability to bind RNA. Smaug a protein that helps to establish a morphogen gradient in Drosophila embryos by repressing the translation of nanos (nos) mRNA binds to the 3' untranslated region (UTR) of nos mRNA via two similar hairpin structures. The 3D crystal structure of the Smaug RNA-binding region shows a cluster of positively charged residues on the Smaug-SAM domain, which could be the RNA-binding surface. This electropositive potential is unique among all previously determined SAM-domain structures and is conserved among Smaug-SAM homologs. These results suggest that the SAM domain might have a primary role in RNA binding.Structural analyses show that the SAM domain is arranged in a small five-helix bundle with two large interfaces. In the case of the SAM domain of EPHB2, each of these interfaces is able to form dimers. The presence of these two distinct intermonomers binding surface suggest that SAM could form extended polymeric structures.".
- Sterile_alpha_motif symbol "SAM_1".
- Sterile_alpha_motif symbol "Ste50p-SAM".
- Sterile_alpha_motif thumbnail PDB_1uqv_EBI.jpg?width=300.
- Sterile_alpha_motif wikiPageExternalLink 17705.
- Sterile_alpha_motif wikiPageID "29545222".
- Sterile_alpha_motif wikiPageRevisionID "593095981".
- Sterile_alpha_motif caption "SAM domain from fungal protein Ste50p".
- Sterile_alpha_motif cdd "cd09487".
- Sterile_alpha_motif hasPhotoCollection Sterile_alpha_motif.
- Sterile_alpha_motif interpro "IPR001660".
- Sterile_alpha_motif interpro "IPR015316".
- Sterile_alpha_motif name "SAM domain".
- Sterile_alpha_motif name "Ste50p-SAM".
- Sterile_alpha_motif pdb "A:10-68 A:596-654 :930-993 E:911-975 A:911-975 A:932-992 C:804-869 D:804-869 A:1511-1575".
- Sterile_alpha_motif pfam "PF00536".
- Sterile_alpha_motif pfam "PF09235".
- Sterile_alpha_motif pfamClan "CL0003".
- Sterile_alpha_motif scop "1".
- Sterile_alpha_motif smart "SAM".
- Sterile_alpha_motif symbol "SAM_1".
- Sterile_alpha_motif symbol "Ste50p-SAM".
- Sterile_alpha_motif subject Category:Protein_domains.
- Sterile_alpha_motif subject Category:Protein_structural_motifs.
- Sterile_alpha_motif type Artifact100021939.
- Sterile_alpha_motif type Decoration103169390.
- Sterile_alpha_motif type Design103178782.
- Sterile_alpha_motif type Motif103789014.
- Sterile_alpha_motif type Object100002684.
- Sterile_alpha_motif type PhysicalEntity100001930.
- Sterile_alpha_motif type ProteinStructuralMotifs.
- Sterile_alpha_motif type Whole100003553.
- Sterile_alpha_motif type Biomolecule.
- Sterile_alpha_motif type Protein.
- Sterile_alpha_motif type BiologicalObject.
- Sterile_alpha_motif comment "In molecular biology, the protein domain Sterile alpha motif (or SAM) is a putative protein interaction module present in a wide variety of proteins involved in many biological processes. The SAM domain that spreads over around 70 residues is found in diverse eukaryotic organisms.".
- Sterile_alpha_motif label "Sterile alpha motif".
- Sterile_alpha_motif sameAs m.0ds0p4w.
- Sterile_alpha_motif sameAs Q7611332.
- Sterile_alpha_motif sameAs Q7611332.
- Sterile_alpha_motif sameAs Sterile_alpha_motif.
- Sterile_alpha_motif wasDerivedFrom Sterile_alpha_motif?oldid=593095981.
- Sterile_alpha_motif depiction PDB_1uqv_EBI.jpg.
- Sterile_alpha_motif isPrimaryTopicOf Sterile_alpha_motif.