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- Stiff_person_syndrome abstract "Stiff person syndrome (SPS) is a rare neurologic disorder of unclear etiology characterized by progressive rigidity and stiffness. The stiffness primarily affects the truncal muscles and is superimposed by spasms, resulting in postural deformities. Chronic pain, impaired mobility, and lumbar hyperlordosis are common symptoms. Spasms can be violent and unpredictable, sometimes breaking bones and often leaving sufferers afraid to leave the home. Patients become very sensitive to touch and sound, which can sometimes trigger spasms. The exact mechanism of the condition is unclear. It has been established that SPS patients generally have glutamic acid decarboxylase antibodies, which seldom occur in the general population. The antibodies are often thought to be the cause of the condition.SPS is difficult to diagnose because there is no specific laboratory test that confirms its presence. Cerebrospinal fluid and Electromyography tests can help confirm the condition's presence by finding antibodies against GAD and involuntary motor unit firing. Early recognition and treatment slow the disease's progression, but a majority of patients eventually are unable to function independently. Benzodiazepine-class drugs are the most common treatment; they are used for symptom relief from stiffness. Other common treatments include Baclofen and Intravenous immunoglobin. SPS occurs in about one in a million people and is most commonly found in middle-aged people. A small minority of patients have the paraneoplastic variety of the condition. Another variant of the condition, stiff-limb syndrome, primarily affects a specific limb. SPS was first described in 1956. Diagnostic criteria were proposed in the 1960s and refined two decades later. In the 1990s and 2000s the roles of antibodies in the condition became more clear.".
- Stiff_person_syndrome wikiPageID "2574140".
- Stiff_person_syndrome wikiPageRevisionID "606606582".
- Stiff_person_syndrome hasPhotoCollection Stiff_person_syndrome.
- Stiff_person_syndrome wordnet_type synset-disease-noun-1.
- Stiff_person_syndrome subject Category:Ailments_of_unknown_etiology.
- Stiff_person_syndrome subject Category:Extrapyramidal_and_movement_disorders.
- Stiff_person_syndrome subject Category:Rare_diseases.
- Stiff_person_syndrome type Abstraction100002137.
- Stiff_person_syndrome type Ailment114055408.
- Stiff_person_syndrome type AilmentsOfUnknownEtiology.
- Stiff_person_syndrome type Attribute100024264.
- Stiff_person_syndrome type Condition113920835.
- Stiff_person_syndrome type Disorder114052403.
- Stiff_person_syndrome type PhysicalCondition114034177.
- Stiff_person_syndrome type State100024720.
- Stiff_person_syndrome type AilmentCondition.
- Stiff_person_syndrome comment "Stiff person syndrome (SPS) is a rare neurologic disorder of unclear etiology characterized by progressive rigidity and stiffness. The stiffness primarily affects the truncal muscles and is superimposed by spasms, resulting in postural deformities. Chronic pain, impaired mobility, and lumbar hyperlordosis are common symptoms. Spasms can be violent and unpredictable, sometimes breaking bones and often leaving sufferers afraid to leave the home.".
- Stiff_person_syndrome label "Sindrome dell'uomo rigido".
- Stiff_person_syndrome label "Stiff person syndrome".
- Stiff_person_syndrome label "Stiff-man-Syndrom".
- Stiff_person_syndrome label "Síndrome de la persona rígida".
- Stiff_person_syndrome label "Zespół sztywności uogólnionej".
- Stiff_person_syndrome label "Синдром мышечной скованности".
- Stiff_person_syndrome label "スティッフパーソン症候群".
- Stiff_person_syndrome sameAs Stiff-man-Syndrom.
- Stiff_person_syndrome sameAs Síndrome_de_la_persona_rígida.
- Stiff_person_syndrome sameAs Sindrome_dell'uomo_rigido.
- Stiff_person_syndrome sameAs スティッフパーソン症候群.
- Stiff_person_syndrome sameAs Zespół_sztywności_uogólnionej.
- Stiff_person_syndrome sameAs m.07n_81.
- Stiff_person_syndrome sameAs Q1235785.
- Stiff_person_syndrome sameAs Q1235785.
- Stiff_person_syndrome sameAs Stiff_person_syndrome.
- Stiff_person_syndrome wasDerivedFrom Stiff_person_syndrome?oldid=606606582.
- Stiff_person_syndrome isPrimaryTopicOf Stiff_person_syndrome.